Browsing University of Galway Theses by Author "Cancer Care West Hardiman Scholarship"
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Maintenance of the spindle assembly checkpoint by PLK1 and CDC7 kinases and characterisation of cell lines carrying mutations in the genes coding for the CDC7 regulatory subunits
O'Connor, Aisling (2016-11-15)The Spindle Assembly Checkpoint (SAC) ensures that accurate chromosome segregation occurs, by preventing progression into anaphase until all kinetochore-microtubule attachments are stable and bi-polar. During a mitotic ...