Browsing University of Galway Theses by Title
Now showing items 2076-2095 of 2276
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Synthesis and Application of Novel Peptidic and Oxazoline Based Ligands for Asymmetric Catalysis
(2012-09-28)This thesis describes the synthesis and application of four novel chiral ligand classes. These were all hydroxyamide or oxazoline ligands with an L-pyroglutamic acid derived terminus. These ligands ... -
Synthesis and application of novel chiral 4,4' PheBOX ligands in asymmetric catalysis and Immobilisation study using 2,2'-PyBOX
(14-10-17)A great deal is known about the reactivity of catalysts derived from 2,2'-PyBOX and 2,2'-PheBOX ligands in asymmetric reactions. The initial aim of this research was to investigate a new type of bisoxazoline ligand, where ... -
Synthesis and characterisation of novel metal organic frameworks for biomedical and environmental applications
(NUI Galway, 2021-09-09)Metal organic frameworks (MOFs) have received significant attention in recent years in the areas of biomedical and environmental applications. Among them, mixed metal MOFs and highly porous MOFs, although promising, are ... -
Synthesis and characterisation of new metal-organic frameworks as carriers of antibacterial agents
(NUI Galway, 2024-04-18)Metal Organic Frameworks are highly porous, crystalline materials that have been used for a multitude of applications, with drug delivery and sensing at the forefront. These frameworks are extremely versatile and can ... -
Synthesis and characterization of new metal-organic frameworks by the use of 2-Pyridyl oximes or alcohols in combination with poly-carboxylic ligands
(NUI Galway, 2022-01-27)The aim of this project is the synthesis and characterization of novel mixed-ligand coordination polymers and metal-organic frameworks (MOFs) and their further study as magnetic sensors for the adsorption of non-environmental ... -
Synthesis and evaluation of glycomimetic inhibitors of infectious diseases
(NUI Galway, 2023-01-04)Sialic acids are a family of 9-carbon α-keto acid monosaccharides. Sialic acids are critical factors in various biological events, which will be discussed over the course of this thesis. Chapter 1 provides a literature ... -
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and ... -
Synthesis and investigation of artificial metallonucleases
(2015-04-29)The aim of this work is the synthesis and investigation of artificial metallonucleases. In the first part of this work a simple model system was used allowing for the quantification of the artificial nucleases ability. ... -
Synthesis of Iminosugar C-Glycosides via Tandem Allylic Azide Rearrangement - Huisgen Cycloaddition
(2013-12-16)Iminosugars are naturally occurring polyhydroxylated alkaloids. These natural mimics of carbohydrates have found clinical use with their biological activity mainly attributed to their inhibition of glycoprocessing enzymes. ... -
Synthesis of model compounds acting as Nitric Oxide (NO)-scavengers and the fabrication of NO-scavenging hydrogels targeting the treatment of triple-negative breast cancer
(NUI Galway, 2023-07-31)Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with an early recurrence within two to three years of first diagnosis. Moreover, the heterogeneity of the TNBC tissue creates ... -
Synthesis of novel glycolipids and investigation into the anomerisation of selenium glycosides
(2016-07-14)The first section of this thesis describes the synthesis of novel glycosphingolipids with an α-triazole at the anomeric carbon. Glycosphingolipids are amphiphilic molecules containing a carbohydrate head glycosidically ... -
Synthesis of s-glycolipids and peptidomimetics
(2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ... -
Synthesis of S-glycolipids and peptidomimetics
(2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ... -
A synthesis of systems engineering tools to improve patient safety, quality and efficiency in health care
(NUI Galway, 2021-04-13)Cancer occurrence has given rise to high risks and deaths of patients all over the world. The consistent negative impact of cancer on humans have spurred healthcare providers and administrators to judiciously search for ... -
Synthesis of tumour cell migration inhibitors
(2012-09-17)Chapter one and two of this thesis describe the synthesis of novel migrastatin derivatives. Migrastatin is a fourteen-membered macrocycle isolated by Japanese researchers from the Streptomyces platensis. It has been shown ... -
Synthetic investigations into discrete polynuclear cage formation and their subsequent incorporation into extended network materials
(2015-01-20)This thesis details the synthesis and structural characterisation of thirty novel complexes via the utilisation of a variety of ligands (seven in total) including hydroxamic acids, Schiff base ligands and their hybrid ... -
Synthetic, Structural, Spectroscopic and Theoretical Studies on Homo- and Heterometallic Paramagnetic Complexes
(2013-01-08)This thesis covers many areas within the field of molecular magnetism. With the exception of chapter 6, all novel complexes in this thesis have been synthesized using the bidentate ligand 2,2'-biphenol (LH2), usually in ... -
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(NUI Galway, 2019-04-23)Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement ... -
A systems engineering approach to equipment qualification in healthcare
(2015-08)Equipment Qualification is a formal quality assurance process in manufacturing which establishes confidence that specified equipment is ‘ready for its intended use’. This thesis, in drawing parallels between requirements ... -
Systems thinking and system dynamics simulation for sustainability education
(NUI Galway, 2022-01-28)Education for Sustainable Development (ESD) is considered vital to the success of the United Nation’s Sustainable Development Goals. Similarly, a good level of Ocean Literacy in the population and in governance is seen as ...