Investigation of the effect of dehydration on tissue dielectric properties in ex vivo measurements
Dwyer, Róisín M.
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Shahzad, Atif; Khan, Sonja; Jones, Marggie; Dwyer, Roisin M; O’Halloran, Martin (2017). Investigation of the effect of dehydration on tissue dielectric properties in ex vivo measurements. Biomedical Physics & Engineering Express 3 (4),
This paper discusses the impact of tissue dehydration on the dielectric properties of excised tissue samples. The effect of dehydration on the tissue surface has been characterized as a function of time after excision on freshly excised mouse liver. The dielectric properties of liver were measured over the frequency range of 500 MHz-20 GHz using an open-ended coaxial probe. Tissue samples were obtained from 7 athymic BALB/c Nude mice, and measurements were performed over the first 3.5 h post-excision at the tissue surface and in the middle of the sample (accessed via a small incision). The samples were kept in sealed containers between measurements to avoid excessive dehydration. The measured dielectric data show a change of more than 25% in both the real and imaginary parts of complex permittivity over 3.5 h after excision. Results indicate the impact of tissue dehydration on the dielectric properties, and signify the importance of considering controls in the experimental design of ex vivo dielectric measurements.
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