dc.contributor.author | Kwenda, Lucretia | |
dc.contributor.author | Collins, Caitriona M. | |
dc.contributor.author | Dattoli, Anna A. | |
dc.contributor.author | Dunleavy, Elaine M. | |
dc.date.accessioned | 2018-09-20T16:13:45Z | |
dc.date.available | 2018-09-20T16:13:45Z | |
dc.date.issued | 2016-04-15 | |
dc.identifier.citation | Kwenda, Lucretia; Collins, Caitriona M. Dattoli, Anna A.; Dunleavy, Elaine M. (2016). Nucleolar activity and cenp-c regulate cenp-a and cal1 availability for centromere assembly in meiosis. Development 143 (8), 1400-1412 | |
dc.identifier.issn | 0950-1991,1477-9129 | |
dc.identifier.uri | http://hdl.handle.net/10379/12342 | |
dc.description.abstract | The centromere-specific histone CENP-A is the key epigenetic determinant of centromere identity. Whereas most histones are removed from mature sperm, CENP-A is retained to mark paternal centromeres. In Drosophila males we show that the centromere assembly factors CAL1 and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility. In meiosis, CENP-A accumulates with CAL1 in nucleoli. Furthermore, we show that CENP-C normally limits the release of CAL1 and CENP-A from nucleoli for proper centromere assembly in meiotic prophase I. Finally, we show that RNA polymerase I transcription is required for efficient CENP-A assembly in meiosis, as well as centromere tethering to nucleoli. | |
dc.publisher | The Company of Biologists | |
dc.relation.ispartof | Development | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | centromere | |
dc.subject | meiosis | |
dc.subject | spermatogenesis | |
dc.subject | cenp-a | |
dc.subject | cid | |
dc.subject | nucleolus | |
dc.subject | sister-chromatid cohesion | |
dc.subject | drosophila-melanogaster | |
dc.subject | epigenetic regulation | |
dc.subject | temporal control | |
dc.subject | maintenance | |
dc.subject | mitosis | |
dc.subject | spermatogenesis | |
dc.subject | transcription | |
dc.subject | segregation | |
dc.subject | propagation | |
dc.title | Nucleolar activity and cenp-c regulate cenp-a and cal1 availability for centromere assembly in meiosis | |
dc.type | Article | |
dc.identifier.doi | 10.1242/dev.130625 | |
dc.local.publishedsource | http://dev.biologists.org/content/143/8/1400.full.pdf | |
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