Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture
Abbah, Sunny A.
Zeugolis, Dimitrios I.
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Abbah, Sunny A. Thomas, Dilip; Browne, Shane; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I. (2016). Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture. Scientific Reports 6 ,
Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-beta 1). In tendon tissue repair, increased activity of TGF-beta 1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by exerting a neutralising effect via downregulation of TGF-beta 1. Herein, we report that the delivery of DCN and IL-10 transgenes from a collagen hydrogel system supresses the constitutive expression of TGF-beta 1 and a range of pro-fibrotic extracellular matrix genes.