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dc.contributor.authorAbbah, Sunny A.
dc.contributor.authorThomas, Dilip
dc.contributor.authorBrowne, Shane
dc.contributor.authorO’Brien, Timothy
dc.contributor.authorPandit, Abhay
dc.contributor.authorZeugolis, Dimitrios I.
dc.date.accessioned2018-09-20T15:58:26Z
dc.date.available2018-09-20T15:58:26Z
dc.date.issued2016-02-10
dc.identifier.citationAbbah, Sunny A. Thomas, Dilip; Browne, Shane; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I. (2016). Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture. Scientific Reports 6 ,
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/10060
dc.description.abstractExtracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-beta 1). In tendon tissue repair, increased activity of TGF-beta 1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by exerting a neutralising effect via downregulation of TGF-beta 1. Herein, we report that the delivery of DCN and IL-10 transgenes from a collagen hydrogel system supresses the constitutive expression of TGF-beta 1 and a range of pro-fibrotic extracellular matrix genes.
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectgrowth-factor-beta
dc.subjecthuman skin fibroblasts
dc.subjectcells in-vitro
dc.subjecttgf-beta
dc.subjecttendon repair
dc.subjectdifferential regulation
dc.subjectpatellar tendinopathy
dc.subjecttumor-cells
dc.subjectdelivery
dc.subjectcollagen
dc.titleCo-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture
dc.typeArticle
dc.identifier.doi10.1038/srep20922
dc.local.publishedsourcehttp://www.nature.com/articles/srep20922.pdf
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland