Browsing Externally hosted open access publications with University of Galway authors (2) by Subject "saccharomyces-cerevisiae"
Now showing items 1-20 of 20
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53bp1: function and mechanisms of focal recruitment
(Portland Press Ltd., 2009-08-01)53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of ... -
Atr activates the s-m checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset
(Elsevier BV, 2013-11-01)Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent ... -
Extracellular vesicles from paracoccidioides pathogenic species transport polysaccharide and expose ligands for dc-sign receptors
(Springer Nature, 2015-09-21)Extracellular vesicles (EVs) mediate non-conventional transport of molecules across the fungal cell wall. We aimed at describing the carbohydrate composition and surface carbohydrate epitopes of EVs isolated from the ... -
Fungal enzymes for bio-products from sustainable and waste biomass
(Elsevier BV, 2016-07-01)Lignocellulose, the most abundant renewable carbon source on earth, is the logical candidate to replace fossil carbon as the major biofuel raw material. Nevertheless, the technologies needed to convert lignocellulose into ... -
Heritability in the efficiency of nonsense-mediated mrna decay in humans
(Public Library of Science (PLoS), 2010-07-21)Background: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated ... -
Increased sister chromatid cohesion and dna damage response factor localization at an enzyme-induced dna double-strand break in vertebrate cells
(Oxford University Press (OUP), 2009-08-21)The response to DNA damage in vertebrate cells involves successive recruitment of DNA signalling and repair factors. We used light microscopy to monitor the genetic dependencies of such localization to a single, induced ... -
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01) -
Mechanisms for atp-dependent chromatin remodelling: the means to the end
(Wiley-Blackwell, 2011-09-08)Chromatin remodelling is the ATP-dependent change in nucleosome organisation driven by Snf2 family ATPases. The biochemistry of this process depends on the behaviours of ATP-dependent motor proteins and their dynamic ... -
Mrc1, tof1 and csm3 inhibit cag·ctg repeat instability by at least two mechanisms
(Elsevier BV, 2008-04-01)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion rates. ... -
Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
(Oxford University Press (OUP), 2012-08-30)Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ... -
Regulation of cdc45 in the cell cycle and after dna damage
(Portland Press Ltd., 2009-08-01)The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. In addition, it is the main target for a Chk1 (checkpoint ... -
Regulation of the dna damage response and gene expression by the dot1l histone methyltransferase and the 53bp1 tumour suppressor
(Public Library of Science (PLoS), 2011-02-24)Background: Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ... -
Repression of g1/s transcription is mediated via interaction of the gtb motifs of nrm1 and whi5 with swi6
(American Society for Microbiology, 2013-02-04)In Saccharomyces cerevisiae, G(1)/S transcription factors MBF and SBF regulate a large family of genes important for entry to the cell cycle and DNA replication and repair. Their regulation is crucial for cell viability, ... -
Roles of vertebrate smc5 in sister chromatid cohesion and homologous recombinational repair
(American Society for Microbiology, 2011-01-18)The structural maintenance of chromosomes (Smc) family members Smc5 and Smc6 are both essential in budding and fission yeasts. Yeast smc5/6 mutants are hypersensitive to DNA damage, and Smc5/6 is recruited to HO-induced ... -
Segregation of replicative dna polymerases during s phase
(American Society for Biochemistry & Molecular Biology (ASBMB), 2012-08-10)DNA polymerases (Pol) alpha, delta, and is an element of replicate the bulk of chromosomal DNA in eukaryotic cells, Pol is an element of being the main leading strand and Pol delta the lagging strand DNA polymerase. By ... -
Structure-function analysis of hmo1 unveils an ancestral organization of hmg-box factors involved in ribosomal dna transcription from yeast to human
(Oxford University Press (OUP), 2013-09-09)Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNA polymerase I transcribed ribosomal ... -
The 26s proteasome drives trinucleotide repeat expansions
(Oxford University Press (OUP), 2013-04-24)Trinucleotide repeat (TNR) expansion is the causative mutation for at least 17 inherited neurological diseases. An important question in the field is which proteins drive the expansion process. This study reports that the ... -
The cenp-t/-w complex is a binding partner of the histone chaperone fact
(Cold Spring Harbor Laboratory, 2016-06-01)The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W ... -
The nse2/mms21 sumo ligase of the smc5/6 complex in the maintenance of genome stability
(Wiley-Blackwell, 2011-05-04) -
Viral proteins as a potential driver of histone depletion in dinoflagellates
(Springer Nature, 2018-04-18)Within canonical eukaryotic nuclei, DNA is packaged with highly conserved histone proteins into nucleosomes, which facilitate DNA condensation and contribute to genomic regulation. Yet the dinoflagellates, a group of ...