Now showing items 1-20 of 53

    • 19p13.1 is a triple-negative-specific breast cancer susceptibility locus 

      Stevens, K. N.; Fredericksen, Z.; Vachon, C. M.; Wang, X.; Margolin, S.; Lindblom, A.; Nevanlinna, H.; Greco, D.; Aittomaki, K.; Blomqvist, C.; Chang-Claude, J.; Vrieling, A.; Flesch-Janys, D.; Sinn, H.-P.; Wang-Gohrke, S.; Nickels, S.; Brauch, H.; Ko, Y.-D.; Fischer, H.-P.; Schmutzler, R. K.; Meindl, A.; Bartram, C. R.; Schott, S.; Engel, C.; Godwin, A. K.; Weaver, J.; Pathak, H. B.; Sharma, P.; Brenner, H.; Muller, H.; Arndt, V.; Stegmaier, C.; Miron, P.; Yannoukakos, D.; Stavropoulou, A.; Fountzilas, G.; Gogas, H. J.; Swann, R.; Dwek, M.; Perkins, A.; Milne, R. L.; Benitez, J.; Zamora, M. P.; Perez, J. I. A.; Bojesen, S. E.; Nielsen, S. F.; Nordestgaard, B. G.; Flyger, H.; Guenel, P.; Truong, T.; Menegaux, F.; Cordina-Duverger, E.; Burwinkel, B.; Marme, F.; Schneeweiss, A.; Sohn, C.; Sawyer, E.; Tomlinson, I.; Kerin, M. J.; Peto, J.; Johnson, N.; Fletcher, O.; dos Santos Silva, I.; Fasching, P. A.; Beckmann, M. W.; Hartmann, A.; Ekici, A. B.; Lophatananon, A.; Muir, K.; Puttawibul, P.; Wiangnon, S.; Schmidt, M. K.; Broeks, A.; Braaf, L. M.; Rosenberg, E. H.; Hopper, J. L.; Apicella, C.; Park, D. J.; Southey, M. C.; Swerdlow, A. J.; Ashworth, A.; Orr, N.; Schoemaker, M. J.; Anton-Culver, H.; Ziogas, A.; Bernstein, L.; Dur, C. C.; Shen, C.-Y.; Yu, J.-C.; Hsu, H.-M.; Hsiung, C.-N.; Hamann, U.; Dunnebier, T.; Rudiger, T.; Ulmer, H. U.; Pharoah, P. P.; Dunning, A. M.; Humphreys, M. K.; Wang, Q.; Cox, A.; Cross, S. S.; Reed, M. W.; Hall, P.; Czene, K.; Ambrosone, C. B.; Ademuyiwa, F.; Hwang, H.; Eccles, D. M.; Garcia-Closas, M.; Figueroa, J. D.; Sherman, M. E.; Lissowska, J.; Devilee, P.; Seynaeve, C.; Tollenaar, R. A. E. M.; Hooning, M. J.; Andrulis, I. L.; Knight, J. A.; Glendon, G.; Mulligan, A. M.; Winqvist, R.; Pylkas, K.; Jukkola-Vuorinen, A.; Grip, M.; John, E. M.; Miron, A.; Alnaes, G. G.; Kristensen, V.; Borresen-Dale, A.-L.; Giles, G. G.; Baglietto, L.; McLean, C. A.; Severi, G.; Kosel, M. L.; Pankratz, V. S.; Slager, S.; Olson, J. E.; Radice, P.; Peterlongo, P.; Manoukian, S.; Barile, M.; Lambrechts, D.; Hatse, S.; Dieudonne, A.-S.; Christiaens, M.-R.; Chenevix-Trench, G.; Beesley, J.; Chen, X.; Mannermaa, A.; Kosma, V.-M.; Hartikainen, J. M.; Soini, Y.; Easton, D. F.; Couch, F. J.; ,; ,; , (American Association for Cancer Research (AACR), 2012-02-13)
      The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of ...
    • 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the breast cancer association consortium 

      Warren, H.; Dudbridge, F.; Fletcher, O.; Orr, N.; Johnson, N.; Hopper, J. L.; Apicella, C.; Southey, M. C.; Mahmoodi, M.; Schmidt, M. K.; Broeks, A.; Cornelissen, S.; Braaf, L. M.; Muir, K. R.; Lophatananon, A.; Chaiwerawattana, A.; Wiangnon, S.; Fasching, P. A.; Beckmann, M. W.; Ekici, A. B.; Schulz-Wendtland, R.; Sawyer, E. J.; Tomlinson, I.; Kerin, M.; Burwinkel, B.; Marme, F.; Schneeweiss, A.; Sohn, C.; Guenel, P.; Truong, T.; Laurent-Puig, P.; Mulot, C.; Bojesen, S. E.; Nielsen, S. F.; Flyger, H.; Nordestgaard, B. G.; Milne, R. L.; Benitez, J.; Arias-Perez, J.-I.; Zamora, M. P.; Anton-Culver, H.; Ziogas, A.; Bernstein, L.; Dur, C. C.; Brenner, H.; Muller, H.; Arndt, V.; Langheinz, A.; Meindl, A.; Golatta, M.; Bartram, C. R.; Schmutzler, R. K.; Brauch, H.; Justenhoven, C.; Bruning, T.; Chang-Claude, J.; Wang-Gohrke, S.; Eilber, U.; Dork, T.; Schurmann, P.; Bremer, M.; Hillemanns, P.; Nevanlinna, H.; Muranen, T. A.; Aittomaki, K.; Blomqvist, C.; Bogdanova, N.; Antonenkova, N.; Rogov, Y.; Bermisheva, M.; Prokofyeva, D.; Zinnatullina, G.; Khusnutdinova, E.; Lindblom, A.; Margolin, S.; Mannermaa, A.; Kosma, V.-M.; Hartikainen, J. M.; Kataja, V.; Chenevix-Trench, G.; Beesley, J.; Chen, X.; Lambrechts, D.; Smeets, A.; Paridaens, R.; Weltens, C.; Flesch-Janys, D.; Buck, K.; Behrens, S.; Peterlongo, P.; Bernard, L.; Manoukian, S.; Radice, P.; Couch, F. J.; Vachon, C.; Wang, X.; Olson, J.; Giles, G.; Baglietto, L.; McLean, C. A.; Severi, G.; John, E. M.; Miron, A.; Winqvist, R.; Pylkas, K.; Jukkola-Vuorinen, A.; Grip, M.; Andrulis, I. L.; Knight, J. A.; Mulligan, A. M.; Weerasooriya, N.; Devilee, P.; Tollenaar, R. A. E. M.; Martens, J. W. M.; Seynaeve, C. M.; Hooning, M. J.; Hollestelle, A.; Jager, A.; Tilanus-Linthorst, M. M. A.; Hall, P.; Czene, K.; Liu, J.; Li, J.; Cox, A.; Cross, S. S.; Brock, I. W.; Reed, M. W. R.; Pharoah, P.; Blows, F. M.; Dunning, A. M.; Ghoussaini, M.; Ashworth, A.; Swerdlow, A.; Jones, M.; Schoemaker, M.; Easton, D. F.; Humphreys, M.; Wang, Q.; Peto, J.; dos-Santos-Silva, I.; ,; ,; , (American Association for Cancer Research (AACR), 2012-08-02)
    • A 3′-untranslated region kras variant and triple-negative breast cancer: a case-control and genetic analysis 

      Paranjape, Trupti; Heneghan, Helen; Lindner, Robert; Keane, Florence K; Hoffman, Aaron; Hollestelle, Antoinette; Dorairaj, Jemima; Geyda, Kimberly; Pelletier, Cory; Nallur, Sunitha; Martens, John WM; Hooning, Maartje J; Kerin, Michael; Zelterman, Daniel; Zhu, Yong; Tuck, David; Harris, Lyndsay; Miller, Nicola; Slack, Frank; Weidhaas, Joanne (Elsevier BV, 2011-04-01)
      Background We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. We aimed to investigate ...
    • A cross-sectional study of secondary cardiac care in general practice: impact of personal and practice characteristics 

      Byrne, M. (Oxford University Press (OUP), 2006-02-03)
      Objective. To determine the impact of patient (age, gender, type of and time since diagnosis) and practice (rurality, number of partners, availability of practice nurse) characteristics on secondary cardiac care in general ...
    • A mixed methods study to assess the feasibility of a randomised controlled trial of invasive urodynamic testing versus clinical assessment and non-invasive tests prior to surgery for stress urinary incontinence in women: the investigate-i study 

      Hilton, Paul; ,; Armstrong, Natalie; Brennand, Catherine; Howel, Denise; Shen, Jing; Bryant, Andrew; Tincello, Douglas G.; Lucas, Malcolm G.; Buckley, Brian S.; Chapple, Christopher R.; Homer, Tara; Vale, Luke; McColl, Elaine (Springer Nature, 2015-09-08)
      Background: The position of invasive urodynamic testing (IUT) in diagnostic pathways for urinary incontinence is unclear, and systematic reviews have called for further trials evaluating clinical utility. The objective of ...
    • A qualitative study of the development of health literacy capacities of participants attending a community-based cardiovascular health programme 

      McKenna, Verna; Sixsmith, Jane; Barry, Margaret (MDPI AG, 2018-06-02)
      Health literacy is a critical determinant of health, which can empower individuals and lead to engagement in collective health promotion action and is also a crucial component in the self-management of illness. The current ...
    • A retrospective cohort study of u.s. service members returning from afghanistan and iraq: is physical health worsening over time? 

      Falvo, Michael J; Serrador, Jorge M; McAndrew, Lisa M; Chandler, Helena K; Lu, Shou-En; Quigley, Karen S (Springer Nature, 2012-12-01)
      Background: High rates of mental health disorders have been reported in veterans returning from deployment to Afghanistan (Operation Enduring Freedom: OEF) and Iraq (Operation Iraqi Freedom: OIF); however, less is known ...
    • Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample 

      Helmi, Luqman; Meagher, David; O’Mahony, Edmond; O’Neill, Donagh; Mulligan, Owen; Murthy, Sutha; McCarthy, Geraldine; Adamis, Dimitrios (Baishideng Publishing Group Inc., 2016-01-01)
      AIM To explore the agreement between the mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) within community dwelling older patients attending an old age psychiatry service and to derive and test ...
    • Chronic pain syndromes after ischemic stroke: profess trial 

      O'Donnell, M. J.; Diener, H.-C.; Sacco, R. L.; Panju, A. A.; Vinisko, R.; Yusuf, S.; , (Ovid Technologies (Wolters Kluwer Health), 2013-04-04)
      Background and Purpose-Chronic pain syndromes are reported to be common after stroke, but most previous epidemiological studies have generally included small cohorts of patients with relatively short-term follow-up. In a ...
    • Comparing approaches to optimize cut-off scores for short cognitive screening instruments in mild cognitive impairment and dementia 

      O’Caoimh, Rónán; Gao, Yang; Svendovski, Anton; Gallagher, Paul; Eustace, Joseph; Molloy, D. William (IOS Press, 2017-03-04)
      Background: Although required to improve the usability of cognitive screening instruments (CSIs), the use of cut-off scores is controversial yet poorly researched. Objective: To explore cut-off scores for two short CSIs: ...
    • Comparing type 1 and type 2 diabetes in pregnancy- similar conditions or is a separate approach required? 

      Owens, Lisa A; Sedar, Jon; Carmody, Louise; Dunne, Fidelma (Springer Nature, 2015-03-27)
      Background: Pregnancy in women with type 1 (T1DM) or type 2 diabetes (T2DM) is associated with increased risk. These conditions are managed similarly during pregnancy, and compared directly in analyses, however they affect ...
    • Comparison of the quick mild cognitive impairment (qmci) screen to the montreal cognitive assessment (moca) in an australian geriatrics clinic 

      Clarnette, Roger; O'Caoimh, Rónán; Antony, Deanna N.; Svendrovski, Anton; Molloy, D. William (Wiley-Blackwell, 2016-07-18)
    • Cross-sectional analysis of the prevalence and predictors of statin utilisation in ireland with a focus on primary prevention of cardiovascular disease 

      Byrne, Paula; Cullinan, John; Murphy, Catríona; Smith, Susan M (BMJ, 2018-02-01)
      Objective To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary ...
    • Destruction of conspecific bioturbation structures by amphiura filiformis (ophiuroida): evidence from luminophore tracers and in situ time-lapse sediment-profile imagery 

      O Reilly, R; Kennedy, R; Patterson, A (Inter-Research Science Center, 2006-06-13)
      Bioturbation processes of a dense ophiuroid assemblage were studied by in situ time-lapse sediment-profile imagery (t-SPI) and laboratory tracer-experiments. The burrows of 4 Amphiura fliformis (Ophiuroida) individuals ...
    • Does empowerment mediate the effects of psychological factors on mental health, well-being, and recovery in young people? 

      Grealish, Annmarie; Tai, Sara; Hunter, Andrew; Emsley, Richard; Murrells, Trevor; Morrison, Anthony P. (Wiley-Blackwell, 2016-12-30)
      ObjectivesThere is consensus that empowerment is key to recovery from mental health problems, enabling a person to take charge of their life and make informed choices and decisions about their life. However, little is known ...
    • Employment and population, 1996-2016: growth, recession and delayed recovery 

      Cawley, Mary (Geography Publications, 2018)
      Introduction The two decades from 1996 to 2016 included a period of rapid economic growth internationally, until about 2008, followed by a deep recession from which many countries are still recovering.1 These changes ...
    • Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study 

      Brophy, Karen; Ryan, Anthony W; Turner, Graham; Trimble, Valerie; Patel, Kunal D; O'Morain, Colm; Kennedy, Nicholas P; Egan, Brian; Close, Eimear; Lawlor, Garrett; MacMathuna, Padraic; Stevens, Fiona M; Abuzakouk, Mohamed; Feighery, Conleth; Kelleher, Dermot; McManus, Ross (Springer Nature, 2010-05-17)
      Background: Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a ...
    • Evaluation of variants in the chek2, brip1 and palb2 genes in an irish breast cancer cohort 

      McInerney, N. M.; Miller, N.; Rowan, A.; Colleran, G.; Barclay, E.; Curran, C.; Kerin, M. J.; Tomlinson, I. P.; Sawyer, E. (Springer Nature, 2009-09-18)
      It has been proposed that rare variants within the double strand break repair genes CHEK2, BRIP1 and PALB2 predispose to breast cancer. The aim of this study was to evaluate the prevalence of these variants in an Irish ...