Browsing by Title
Now showing items 12755-12774 of 14646
-
The synergistic effects of gold particles and dexamethasone on the electrochemical and biological performance of PEDOT neural interfaces
(MDPI, 2019-01-05)Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim ... -
Synergistic hydrolysis of cellulose by components of the extracellular cellulase system oftalaromyces emersonii
(Wiley-Blackwell, 1980-08-11) -
Synergy between embedding and protein functional association networks for drug label prediction using harmonic function
(ACM and IEEE, 2020-10-16)Semi-Supervised Learning (SSL) is an approach to machine learning that makes use of unlabeled data for training with a small amount of labeled data. In the context of molecular biology and pharmacology, one can take advantage ... -
Syntheses of C-substituted icosahedral dicarbaboranes bearing the 8-dioxane-cobalt bisdicarbollide moiety
(Elsevier, 2009-11-20)The treatment of 1,2-, 1,7- and 1,12-carbaborane lithiated isomers with [3,3′-Co-8-(CH2CH2O)2-(1,2-C2B9H10)-(1′,2′-C2B9H11)] (1) at molar ratios 1:1 or 1:2 at room temperature in THF leads generally to the formation of a ... -
Synthesis and Anti-Cancer Activity of Novel Imidazo[5,4-f]benzimidazolequinones
(2011-08-24)Chapter 1; A literature review of chemotherapeutic agents, bioreductive prodrugs and polycyclic diazoles, along with the aims and objects of the thesis is presented. Chapter 2; A review of 'oxidative' homolytic aromatic ... -
Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis
(2012-11-28)This thesis deals with the design, synthesis and reactivity of novel 4,4'-bisoxazoline ligands and their metal complexes; (S,S)-MePrAraBOX, (S,S)-PhPrAraBOX, (S,R)-MePrAraBOX, (S,R)-PhPrAraBOX, (S,R)-BnOAcAraBOX and ... -
Synthesis and application of chiral substituted oxazolines
(2015-09-08)This thesis consists of two subprojects, dealing with the design, synthesis and application of novel (1) pyridinyl-oxazoline ligands and (2) prolyl-oxazoline ligands. In Project 1 eleven novel pyridinyl-oxazoline ligands ... -
Synthesis and Application of Novel Peptidic and Oxazoline Based Ligands for Asymmetric Catalysis
(2012-09-28)This thesis describes the synthesis and application of four novel chiral ligand classes. These were all hydroxyamide or oxazoline ligands with an L-pyroglutamic acid derived terminus. These ligands ... -
Synthesis and application of novel chiral 4,4' PheBOX ligands in asymmetric catalysis and Immobilisation study using 2,2'-PyBOX
(14-10-17)A great deal is known about the reactivity of catalysts derived from 2,2'-PyBOX and 2,2'-PheBOX ligands in asymmetric reactions. The initial aim of this research was to investigate a new type of bisoxazoline ligand, where ... -
Synthesis and biological evaluation of migrastatin macrotriazoles
(Wiley-Blackwell, 2016-12-05)The synthesis of three macrotriazoles that are analogues of migrastatin is reported. The synthesis is based on copper(I)- and ruthenium-catalyzed azide-alkyne cycloaddition reactions. The enantiopure terminal alkyne ... -
Synthesis and characterisation of novel metal organic frameworks for biomedical and environmental applications
(NUI Galway, 2021-09-09)Metal organic frameworks (MOFs) have received significant attention in recent years in the areas of biomedical and environmental applications. Among them, mixed metal MOFs and highly porous MOFs, although promising, are ... -
Synthesis and characterisation of new metal-organic frameworks as carriers of antibacterial agents
(NUI Galway, 2024-04-18)Metal Organic Frameworks are highly porous, crystalline materials that have been used for a multitude of applications, with drug delivery and sensing at the forefront. These frameworks are extremely versatile and can ... -
Synthesis and characterization of new metal-organic frameworks by the use of 2-Pyridyl oximes or alcohols in combination with poly-carboxylic ligands
(NUI Galway, 2022-01-27)The aim of this project is the synthesis and characterization of novel mixed-ligand coordination polymers and metal-organic frameworks (MOFs) and their further study as magnetic sensors for the adsorption of non-environmental ... -
Synthesis and evaluation of glycomimetic inhibitors of infectious diseases
(NUI Galway, 2023-01-04)Sialic acids are a family of 9-carbon α-keto acid monosaccharides. Sialic acids are critical factors in various biological events, which will be discussed over the course of this thesis. Chapter 1 provides a literature ... -
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and ... -
Synthesis and investigation of artificial metallonucleases
(2015-04-29)The aim of this work is the synthesis and investigation of artificial metallonucleases. In the first part of this work a simple model system was used allowing for the quantification of the artificial nucleases ability. ... -
Synthesis of a spirocyclic oxetane-fused benzimidazole
(MDPI AG, 2015-07-30)A new synthesis of 2-oxa-7-azaspiro[3.5]nonane is described. Spirocyclic oxetanes, including 2-oxa-6-azaspiro[3.3]heptane were converted into o-cycloalkylaminoacetanilides for oxidative cyclizations using Oxone((R)) in ... -
Synthesis of a-O- and a-S-Glycosphingolipids Related to Sphingomonous cell Wall Antigens Using Anomerisation
(MDPI, 2013)[no abstract available] -
Synthesis of a-o- and a-s-glycosphingolipids related to sphingomonous cell wall antigens using anomerisation
(MDPI AG, 2013-09-12)Analogues of glycolipids from Spingomonadacaece with O- and S- and SO2-linkages have been prepared using chelation induced anomerisation promoted by TiCl4. Included are examples of the anomerisation of intermediates with ... -
Synthesis of affinity gels: a re-assessment of the advantages and disadvantages of the modular solid-phase approach
(Portland Press Ltd., 1974-12-01)