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Now showing items 11585-11604 of 14646
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The role of the citizen consumer: alternative consumer actvisim and the rights to health and development
(Commonwealth Secretariat/ Nexus Strategic Partnerships, 2012)This chapter draws on case-study research to show how networked consumer campaigns have shaped global health governance. It highlights the important, yet under-researched role of Southern health activism in mobilising ... -
The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
(NUI Galway, 2020-10-20)Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ... -
The role of the endocannabinoid system in the affective modulation of pain
(2015-09-30)Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ... -
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ... -
The role of the endogenous opioid system in hyperalgesia associated with negative affect
(NUI Galway, 2020-02-26)Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ... -
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
(NUI Galway, 2019-11-11)Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ... -
The Role of the European Union in Ensuring Respect for International Humanitarian Law
(2011-09-23)This research examines the role of the EU and its Member States in contributing to furthering the aims of international humanitarian law and increasing its implementation and effectiveness through its external promotion ... -
The role of the judge in the progressive development of international criminal law
(2017-01-19)International criminal law offers fertile ground for considering the role of the bench in the development of law through creative or progressive interpretative methodologies. Since its genesis at Nuremberg more than 70 ... -
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ... -
The role of the natural aquatic environment in the dissemination of extended spectrum beta-lactamase and carbapenemase encoding genes: A scoping review
(Elsevier, 2020-05-07)The natural aquatic environment is a significant contributor to the development and circulation of clinically significant antibiotic resistance genes (ARGs). The potential for the aquatic environment to act as a reservoir ... -
The role of the pine marten in Irish squirrel population dynamics
(2013-09-19)There are two squirrel species found in Ireland. The native red squirrel, Sciurus vulgaris, and the invasive North American grey squirrel, Sciurus carolinensis. In Ireland, the UK and Italy the grey squirrel threatens ... -
Role of the saccharomyces cerevisiae rad9 protein in sensing and responding to dna damage
(Portland Press Ltd., 2003-02-01)Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including ... -
The role of the user story agile practice in innovation
(Springer, 2010-10)The concept of an innovation space where different knowledge and perspectives can interact leading to innovation is central to lean thinking. The SECI framework of organizational knowledge creation identifies five enabling ... -
Role of thyroxine in chronic urticaria and angio-oedema
(SAGE Publications, 2004-04-30) -
The role of tumour necrosis factor related apoptosis-inducing ligand receptor signalling in tumour immune interactions
(NUI Galway, 2023-09-18)Death receptors are members of the tumor necrosis factor receptor (TNFR) superfamily, characterised by the presence of an intracellular alpha helical fold domain, called the death domain (DD) [1][2]. There are 8 death ... -
The Role of Unconventional T Cells in the Immune Response to the Gastric Pathogen Helicobacter pylori
(2012-09-30)Helicobacter pylori (HP) is a gastric pathogen that is a known causative agent of gastritis, and peptic ulcers. It is a co-factor for the onset of gastric cancer and for these reasons is classified as a type I carcinogen. ... -
Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis
(BMJ, 2013-10-04)Objectives The purpose of this work was to test whether normal peri-entheseal vascular anatomy at anterior and posterior cruciate ligaments (ACL and PCL) was associated with distribution of peri-entheseal bone erosion/bone ... -
The role of wet wipes and sanitary towels as a source of white microplastic fibres in the marine environment
(Elsevier, 2020-06-10)Understanding source elements of the ocean plastic crisis is key to effective pollution reduction management and policy. The ubiquity of microplastic (MP) fibres in the oceans is considered to derive primarily from clothing ... -
The role of work-life balance policies in healthcare human resources management
(2011)Currently a European wide study has surveyed some 1,406 nurses in 115 units within over 30 hospitals as part of a longer study. This study looks at nurses' qualifications, productivity, their working environment as well ... -
Role of b in regulating the compatible solute uptake systems of listeria monocytogenes: osmotic induction of opuc is b dependent
(American Society for Microbiology, 2003-04-01)The regulation of the compatible solute transport systems in Listeria monocytogenes by the stress-inducible sigma factor sigma(B) was investigated. Using wild-type strain 10403S and an otherwise isogenic strain carrying ...