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Now showing items 6358-6377 of 14647
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hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli
(Springer Nature, 2001-01-01)Enhanced cell survival and resistance to apoptosis during thermotolerance correlates with an increased expression of heat shock proteins (Hsps). Here we present additional evidence in support of the hypothesis that the ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
(2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
(Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
hst optical polarimetry of the vela pulsar and nebula
(Oxford University Press (OUP), 2014-09-30)Polarization measurements of pulsars offer a unique insight into the geometry of the emission regions in the neutron star magnetosphere. Therefore, they provide observational constraints on the different models proposed ... -
Hucop1 contributes to the regulation of dna repair in keratinocytes
(Springer Nature, 2016-12-19)We have previously demonstrated that the E3 ligase Human Constitutive Photomorphogenic Protein (huCOP1) is expressed in human keratinocytes and negatively regulates p53. The MutS homolog 2 (MSH2) protein plays a central ... -
Human biomonitoring of glyphosate exposures: State-of-the-art and future research challenges
(MDPI, 2020-08-18)Abstract: Glyphosate continues to attract controversial debate following the International Agency for Research on Cancer carcinogenicity classification in 2015. Despite its ubiquitous presence in our environment, there ... -
Human centred design considerations for connected health devices for the older adult
(MDPI, 2014-06-04)Connected health devices are generally designed for unsupervised use, by non-healthcare professionals, facilitating independent control of the individuals own healthcare. Older adults are major users of such devices ... -
Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel
(2003)The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are ... -
Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the bkcachannel
(The Endocrine Society, 2003-09-01)The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are ... -
Human dignity as a bar to bio-patentability in European Patent Law: An exposé and a novel reform paradigm
(NUI Galway, 2023-10-04)This research addresses a gap found in the literature which is that there is a lack of coherence about the standard of the fundamental, but under-defined, concept of human dignity in European patent law. This problem ... -
Human endogenous retrovirus K (HERV-K) in prostate cancer
(2016-08-08)Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ... -
Human endogenous retrovirus k and cancer: innocent bystander or tumorigenic accomplice?
(Wiley-Blackwell, 2014-06-17)Harbored as relics of ancient germline infections, human endogenous retroviruses (HERVs) now constitute up to 8% of our genome. A proportion of this sequence has been co-opted for molecular and cellular processes, beneficial ... -
Human enhancement, social solidarity and the distribution of responsibility
(Springer Nature, 2015-07-29)This paper tries to clarify, strengthen and respond to two prominent objections to the development and use of human enhancement technologies. Both objections express concerns about the link between enhancement and the drive ... -
Human Flourishing: The Grounds of Moral Judgment
(Springer, 2008) -
Human induced pluripotent stem cells as a model for neurodevelopmental disease
(2015-10-01)Abstract Autism spectrum disorders (ASD) are neurodevelopmental disorders which encompass a wide range of symptoms, including intellectual disability and delayed development, while the phenotype can range from mild to ... -
Human induced pluripotent stem cells as an in vitro model for autism spectrum disorder
(NUI Galway, 2022-08-23)Autism spectrum disorders (ASD) are neurodevelopmental disorders which encompass a wide range of symptoms, including intellectual disability and delayed development, while the phenotype can range from mild to severe. Genetic ... -
Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers
(BMC, 2019-11-19)Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ... -
Human metapneumovirus-associated respiratory tract infections in the republic of ireland during the influenza season of 2003–2004
(Elsevier BV, 2005-05-01)Human metapneumovirus (hMPV) is a newly identified paramyxovirus that has been associated with respiratory tract illness in children aged < 5 years, the elderly, and immunocompromised patients. This study determined the ... -
Human monocyte subset distinctions and function: Insights from gene expression analysis
(Frontiers Media, 2020-06-04)Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ...