Browsing University of Galway Support Services by Subject "ubiquitination"
Now showing items 1-2 of 2
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Distinct brct domains in mcph1/brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
(Springer Nature, 2007-06-25)Microcephalin (MCPH1/BRIT1) forms ionizing radiation-induced nuclear foci (IRIF) and is required for DNA damage-responsive S and G(2)-M-phase checkpoints. MCPH1 contains three BRCT domains. Here we report the cloning of ... -
Inhibition of nedd8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
(American Society of Hematology, 2010-03-04)NEDD8 activating enzyme (NAE) has been identified as an essential regulator of the NEDD8 conjugation pathway, which controls the degradation of many proteins with important roles in cell-cycle progression, DNA damage, and ...