Browsing University of Galway Support Services by Subject "synaptotagmin-i"
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A dileucine in the protease of botulinum toxin a underlies its long-lived neuroparalysis
(American Society for Biochemistry & Molecular Biology (ASBMB), 2010-12-07)Blockade of neurotransmitter release by botulinum neurotoxin type A (BoNT(A)) underlies the severe neuroparalytic symptoms of human botulism, which can last a few years. The structural basis for this remarkable persistence ...