Browsing University of Galway Support Services by Author "Takeda, Shunichi"
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Analysis of scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores
Vagnarelli, Paola; Morrison, Ciaran; Dodson, Helen; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C (Wiley-Blackwell, 2004-02-01)Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation ... -
Centrosome amplification induced by dna damage occurs during a prolonged g2 phase and involves atm
Dodson, Helen; Bourke, Emer; Jeffers, Liam J; Vagnarelli, Paola; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C; Merdes, Andreas; Morrison, Ciaran (Wiley-Blackwell, 2004-09-09)Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after gamma-irradiation and in cells with mutations in DNA repair genes. To investigate ... -
Parp-1 protects homologous recombination from interference by ku and ligase iv in vertebrate cells
Hochegger, Helfrid; Dejsuphong, Donniphat; Fukushima, Toru; Morrison, Ciaran; Sonoda, Eiichiro; Schreiber, Valérie; Zhao, Guang Yu; Saberi, Alihossein; Masutani, Mitsuko; Adachi, Noritaka; Koyama, Hideki; de Murcia, Gilbert; Takeda, Shunichi (Wiley-Blackwell, 2006-02-23)Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or ... -
Proteomics analysis with a nano random forest approach reveals novel functional interactions regulated by smc complexes on mitotic chromosomes
Ohta, Shinya; Montaño-Gutierrez, Luis F.; de Lima Alves, Flavia; Ogawa, Hiromi; Toramoto, Iyo; Sato, Nobuko; Morrison, Ciaran G.; Takeda, Shunichi; Hudson, Damien F.; Rappsilber, Juri; Earnshaw, William C. (American Society for Biochemistry & Molecular Biology (ASBMB), 2016-05-26)Packaging of DNA into condensed chromosomes during mitosis is essential for the faithful segregation of the genome into daughter nuclei. Although the structure and composition of mitotic chromosomes have been studied for ...