Browsing University of Galway Support Services by Author "Nath, Karl A."
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Dendritic cells facilitate accumulation of il-17t cells in the kidney following acute renal obstruction
Dong, Xiangyang; Bachman, Lori A.; Miller, Melinda N.; Nath, Karl A.; Griffin, Matthew D. (Elsevier BV, 2008-11-01)Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) ... -
Interleukin-1 accounts for intrarenal th17 cell activation during ureteral obstruction
Pindjakova, Jana; Hanley, Shirley A.; Duffy, Michelle M.; Sutton, Caroline E.; Weidhofer, Gudrun A.; Miller, Melinda N.; Nath, Karl A.; Mills, Kingston H.G.; Ceredig, Rhodri; Griffin, Matthew D. (Elsevier BV, 2012-02-01)Interleukin 17A-secreting T-helper 17 (Th17) cells are pathogenic in inflammatory kidney diseases, but their intrarenal regulation is poorly understood. In order to better define Th17 cell dynamics during interstitial ...