Browsing University of Galway Support Services by Author "Nasheuer, Heinz-Peter"
Now showing items 1-20 of 21
-
Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by erk-mediated enhancement of hif-1α activity
Fábián, Zsolt; Ramadurai, Sivaramakrishnan; Shaw, Georgina; Nasheuer, Heinz-Peter; Kolch, Walter; Taylor, Cormac; Barry, Frank (Elsevier BV, 2014-05-01) -
Coordinated regulation of replication protein a activities by its subunits p14 and p32
Weisshart, Klaus; Pestryakov, Pavel; Smith, Richard W. P.; Hartmann, Hella; Kremmer, Elisabeth; Lavrik, Olga; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-06-17)The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still ... -
Distinctive activities of dna polymerases during human dna replication
Rytkonen, Anna K.; Vaara, Markku; Nethanel, Tamar; Kaufmann, Gabriel; Sormunen, Raija; Laara, Esa; Nasheuer, Heinz-Peter; Rahmeh, Amal; Lee, Marietta Y. W. T.; Syvaoja, Juhani E.; Pospiech, Helmut (Wiley-Blackwell, 2006-07-01)The contributions of human DNA polymerases (pols) alpha, delta and epsilon during S-phase progression were studied in order to elaborate how these enzymes co-ordinate their functions during nuclear DNA replication. Pol ... -
Dna polymerase ε associates with the elongating form of rna polymerase ii and nascent transcripts
Rytkönen, Anna K.; Hillukkala, Tomi; Vaara, Markku; Sokka, Miiko; Jokela, Maarit; Sormunen, Raija; Nasheuer, Heinz-Peter; Nethanel, Tamar; Kaufmann, Gabriel; Pospiech, Helmut; Syväoja, Juhani E. (Wiley-Blackwell, 2006-11-15)DNA polymerase epsilon co-operates with polymerases alpha and delta in the replicative DNA synthesis of eukaryotic cells. We describe here a specific physical interaction between DNA polymerase epsilon and RNA polymerase ... -
Host-specific replication of bk virus dna in mouse cell extracts is independently controlled by dna polymerase -primase and inhibitory activities
Tikhanovich, I.; Nasheuer, Heinz-Peter (American Society for Microbiology, 2010-04-14)The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immuno-compromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based ... -
Human replication protein a
Pestryakov, Pavel E.; Weisshart, Klaus; Schlott, Bernhard; Khodyreva, Svetlana N.; Kremmer, Elisabeth; Grosse, Frank; Lavrik, Olga I.; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-02-24)Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other ... -
Initiation of jc virus dna replication in vitro by human and mouse dna polymerase alpha-primase
Smith, Richard W. P.; Nasheuer, Heinz-Peter (Wiley-Blackwell, 2003-05-01)Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase alpha-primase complex involved in the initiation of both viral ... -
Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism
Fleming, R.M.T.; Thiele, I.; Provan, G.; Nasheuer, Heinz-Peter (Elsevier BV, 2010-06-01) -
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
Borgstahl, Gloria E.O.; Brader, Kerry; Mosel, Adam; Liu, Shengqin; Kremmer, Elisabeth; Goettsch, Kaitlin A.; Kolar, Carol; Nasheuer, Heinz-Peter; Oakley, Greg G. (Elsevier BV, 2014-09-01) -
Ionizing radiation-dependent and independent phosphorylation of the 32-kda subunit of replication protein a during mitosis
Stephan, Holger; Concannon, Claire; Kremmer, Elisabeth; Carty, Michael P.; Nasheuer, Heinz-Peter (Oxford University Press (OUP), 2009-08-11)The human single-stranded DNA-binding protein, replication protein A (RPA), is regulated by the N-terminal phosphorylation of its 32-kDa subunit, RPA2. RPA2 is hyperphosphorylated in response to various DNA-damaging agents ... -
Modification of histones by sugar β-n-acetylglucosamine (glcnac) occurs on multiple residues, including histone h3 serine 10, and is cell cycle-regulated
Zhang, Suisheng; Roche, Kevin; Nasheuer, Heinz-Peter; Lowndes, Noel Francis (American Society for Biochemistry & Molecular Biology (ASBMB), 2011-09-06)The monosaccharide, beta-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group of either serines or threonines to generate an O-linked beta-N-acetylglucosamine (O-GlcNAc) residue (Love, D. C., and Hanover, J. ... -
Parg is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(adp-ribose) upon prolonged replicative stress
Illuzzi, Giuditta; Fouquerel, Elise; Amé, Jean-Christophe; Noll, Aurélia; Rehmet, Kristina; Nasheuer, Heinz-Peter; Dantzer, Françoise; Schreiber, Valérie (Oxford University Press (OUP), 2014-06-06)Poly(ADP-ribosyl)ation is involved in numerous biological processes including DNA repair, transcription and cell death. Cellular levels of poly(ADP-ribose) (PAR) are regulated by PAR polymerases (PARPs) and the degrading ... -
Physical and functional modularity of the protein network in yeast
Wilhelm, Thomas; Nasheuer, Heinz-Peter; Huang, Sui (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-05-01)While protein-protein interactions have been studied largely as a network graph without physicality, here we analyze two protein complex data sets of Saccharomyces cerevisiae to relate physical and functional modularity ... -
Post-transcriptional expression regulation in the yeastsaccharomyces cerevisiaeon a genomic scale
Beyer, Andreas; Hollunder, Jens; Nasheuer, Heinz-Peter; Wilhelm, Thomas (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-08-23)Based on large-scale data for the yeast Saccharomyces cerevisiae (protein and mRNA abundance, translational status, transcript length), we investigate the relation of transcription, translation, and protein turnover on a ... -
Quantitative assignment of reaction directionality in constraint-based models of metabolism: application to escherichia coli
Fleming, R.M.T.; Thiele, I.; Nasheuer, Heinz-Peter (Elsevier BV, 2009-12-01) -
Regulation of cdc45 in the cell cycle and after dna damage
Broderick, Ronan; Nasheuer, Heinz-Peter (Portland Press Ltd., 2009-08-01)The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. In addition, it is the main target for a Chk1 (checkpoint ... -
Regulation of eukaryotic dna replication at the initiation step
Pollok, S.; Stoepel, J.; Bauerschmidt, C.; Kremmer, E.; Nasheuer, Heinz-Peter (Portland Press Ltd., 2003-02-01)The studies of cell growth and division have remained at the centre of biomedical research for more than 100 years. The combination of genetic, biochemical, molecular and cell biological techniques recently yielded a burst ... -
Restriction of human polyomavirus bk virus dna replication in murine cells and extracts
Mahon, C.; Liang, B.; Tikhanovich, I.; Abend, J. R.; Imperiale, M. J.; Nasheuer, Heinz-Peter; Folk, W. R. (American Society for Microbiology, 2009-03-18)BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ... -
Segregation of replicative dna polymerases during s phase
Vaara, Markku; Itkonen, Harri; Hillukkala, Tomi; Liu, Zhe; Nasheuer, Heinz-Peter; Schaarschmidt, Daniel; Pospiech, Helmut; Syväoja, Juhani E. (American Society for Biochemistry & Molecular Biology (ASBMB), 2012-08-10)DNA polymerases (Pol) alpha, delta, and is an element of replicate the bulk of chromosomal DNA in eukaryotic cells, Pol is an element of being the main leading strand and Pol delta the lagging strand DNA polymerase. By ... -
Stimulation of bk virus dna replication by nfi family transcription factors
Liang, B.; Tikhanovich, I.; Nasheuer, Heinz-Peter; Folk, W. R. (American Society for Microbiology, 2011-12-28)BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pathologies in some individuals. The activation of BKV ...