Browsing Pharmacology & Therapeutics by Author "National Biophotonics and Imaging Platform, Ireland"
Now showing items 1-2 of 2
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Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy
Moriarty, Orla; Lang, Yvonne; Idrees, Zubair; McGuire, Brian E.; Finn, David P. (Elsevier, 2016-01-13)Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and ... -
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
Moriarty, Orla; Gorman, Claire L.; McGowan, Fiona; Ford, Gemma K.; Roche, Michelle; Thompson, Kerry; Dockery, Peter; McGuire, Brian E.; Finn, David P. (De Gruyter, 2016-01-01)Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ...