Browsing College of Medicine, Nursing and Health Sciences by Subject "pain"

Now showing items 1-6 of 6

    • Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex 

      Okine, Bright N.; Mc Laughlin, Gemma; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2020-07-13)
      The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ...

    • Cognition and pain 

      Moriarty, Orla; Finn, David P. (Lippincott, Williams & Wilkins, 2014-06)
      Purpose of reviewPain and cognition share common neural substrates and are known to interact reciprocally. This has implications for treatment and management of pain conditions; pain can negatively affect cognitive ...

    • Evidence for differential modulation of conditioned aversion and fear‐conditioned analgesia by CB1 receptors 

      Finn, David P.; Beckett, S. R. G.; Richardson, D.; Kendall, D. A.; Marsden, C. A.; Chapman, V. (Wiley, 2004-07-15)
      Fear‐conditioned analgesia is an important survival response mediated by substrates controlling nociception and aversion. Cannabinoid1 (CB1) receptors play an important role in nociception and aversion. However, their role ...

    • High times for painful blues: the endocannabinoid system in pain-depression comorbidity 

      Fitzgibbon, Marie; Finn, David P.; Roche, Michelle (Oxford University Press (OUP), 2015-09-05)
      Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ...

    • Oral loratadine in the management of G-CSF induced bone pain: a pilot study 

      Duggan, Caitriona; Murphy, Louise; Costello, Vicky; O Leary, Eilis; Dien Yousif, Ala; Blazcova, Silvie; Dowling, Maura (Mark Allen Healthcare, 2019-02-27)
      This pilot study aimed to ascertain if bone pain induced by granulocyte-colony stimulating factors (G-CSFs) can be alleviated or eliminated by oral antihistamine loratadine. Twelve patients with cancer receiving chemotherapy ...

    • The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner 

      Rea, Kieran; McGowan, Fiona; Corcoran, Louise; Roche, Michelle; Finn, David P. (Wiley, 2018-05-30)
      Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...