Browsing College of Medicine, Nursing and Health Sciences by Author "Fitzgibbon, Marie"
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Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
Fitzgibbon, Marie; Kerr, Daniel M.; Henry, Rebecca J.; Finn, David P.; Roche, Michelle (Elsevier, 2019-09-07)Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ... -
High times for painful blues: the endocannabinoid system in pain-depression comorbidity
Fitzgibbon, Marie; Finn, David P.; Roche, Michelle (Oxford University Press (OUP), 2015-09-05)Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ... -
Ulk4 regulates GABAergic signaling and anxiety-related behavior
Liu, Min; Fitzgibbon, Marie; Wang, Yanqin; Reilly, Jamie; Qian, Xiaohong; O’Brien, Timothy; Clapcote, Steve; Shen, Sanbing; Roche, Michelle (Springer Nature, 2018-02-02)Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...