Browsing College of Medicine, Nursing and Health Sciences by Author "College of Medicine, Nursing and Health Sciences, National University of Ireland Galway"
Now showing items 1-6 of 6
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Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan (Elsevier, 2018-09-26)Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ... -
Cell viability in three ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan S. (Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Exacerbated LPS/GalN-induced liver injury in the stress-sensitive Wistar Kyoto rat is associated with changes in the endocannabinoid system
Killilea, Marykate; Kerr, Daniel M.; Mallard, Beth M.; Roche, Michelle; Wheatley, Antony M. (MDPI, 2020-08-23)Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays a key role in modulating stress and hepatic ... -
Fostering the resilience of people with dementia: A narrative literature review
Whelan, Sally; Teahan, Áine; Casey, Dympna (Frontiers Media, 2020-02-25)Background: Resilience is a process through which people use resources to adapt to adversity. Interventions aiming to support resilience in people with dementia have been developed. However, the optimal content, structure ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
Henry, Rebecca J.; Kerr, Daniel M.; Flannery, Lisa E.; Killilea, Marykate; Hughes, Edel M.; Corcoran, Louise; Finn, David P.; Roche, Michelle (Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ...