Browsing Physiology by Author "Finn, David P."
Now showing items 1-19 of 19
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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
Burke, Nikita N.; Geoghegan, E.; Moriarty, Orla; Finn, David P.; Kerr, Daniel M.; Roche, Michelle (Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
Buckley, David A.; Jennings, Elaine M.; Burke, Nikita N.; Roche, Michelle; McInerney, Veronica; Wren, Jonathan D.; Finn, David P.; McHugh, Patrick C. (Springer, 2017-03-30)Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ... -
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
Fitzgibbon, Marie; Kerr, Daniel M.; Henry, Rebecca J.; Finn, David P.; Roche, Michelle (Elsevier, 2019-09-07)Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ... -
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
Flannery, Lisa E.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Elsevier, 2018-06-25)Aberrant activation of toll-like receptor (TLR)s results in persistent and prolonged neuroinflammation and has been implicated in the pathogenesis and exacerbation of psychiatric and neurodegenerative disorders. TLR3 ... -
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
Flannery, Lisa E.; Henry, Rebecca J.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Wiley, 2017-07-20)Toll-like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3-induced inflammatory, endocrine, and sickness responses. ... -
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
Henry, Rebecca J.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Elsevier, 2015-03-17)Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ... -
High times for painful blues: the endocannabinoid system in pain-depression comorbidity
Fitzgibbon, Marie; Finn, David P.; Roche, Michelle (Oxford University Press (OUP), 2015-09-05)Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ... -
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
Burke, Nikita N.; Llorente, Ricardo; Marco, Eva M.; Tong, Kezanne; Finn, David P.; Viveros, Maria-Paz; Roche, Michelle (Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
Burke, Nikita N.; Kerr, Daniel M.; Moriarty, Orla; Finn, David P.; Roche, Martin (Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ... -
Neuroinflammatory mechanisms linking pain and depression
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Karger, 2015)Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ... -
Pharmacological blockade of PPARα exacerbates inflammatory pain-related impairment of spatial memory in rats
Gaspar, Jessica C.; Healy, Catherine; Ferdousi, Mehnaz I.; Roche, Michelle; Finn, David P. (MDPI, 2021-05-27)Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPAR¿, PPARß/¿ and PPAR¿. Studies suggest that the PPAR signalling system may modulate pain, ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
Henry, Rebecca J.; Kerr, Daniel M.; Flannery, Lisa E.; Killilea, Marykate; Hughes, Edel M.; Corcoran, Louise; Finn, David P.; Roche, Michelle (Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
Hughes, Edel M.; Calcagno, Patricia; Clarke, Morgane; Sanchez, Connie; Smith, Karen; Kelly, John P.; Finn, David P.; Roche, Michelle (Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
Burke, Nikita N.; Finn, David P.; McGuire, Brian E.; Roche, Michelle (Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
Okine, B. N.; Rea, K.; Olango, W. M.; Price, J.; Herdman, S.; Madasu, M. K.; Roche, Michelle; Finn, David P. (Wiley, 2013-12-05)Background and Purpose The nuclear hormone receptor, PPARα, and its endogenous ligands, are involved in pain modulation. PPARα is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
Burke, Nikita N.; Coppinger, Jonathan; Deaver, Daniel R.; Roche, Michelle; Finn, David P.; Kelly, John (Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ...