Browsing Physiology by Author "O'Kennedy, Richard"
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Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
O'Kennedy, Richard; Fitzgerald, Seán; Murphy, Caroline (Elsevier, 2017-01-30)Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ... -
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer
Fitzgerald, Seán; Sheehan, Katherine M.; Espina, Virginia; O'Grady, Anthony; Cummins, Robert; Kenny, Dermot; Liotta, Lance; O'Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (Wiley, 2014-11-13)Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ... -
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
Fitzgerald, Seán; Sheehan, Katherine M.; O'Grady, Anthony; Kenny, Dermot; O'Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (Wiley, 2013-02-21)Background and Aim TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ...