Browsing Physiology by Author "Kelly, John P."
Now showing items 1-6 of 6
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Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Doyle, Karen M. (Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Dockery, Peter; Doyle, Karen M. (Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
Hughes, Edel M.; Calcagno, Patricia; Clarke, Morgane; Sanchez, Connie; Smith, Karen; Kelly, John P.; Finn, David P.; Roche, Michelle (Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
Moreira da Silva Santos, Andreia; Gorman, Adrienne M.; Kelly, John P.; Doyle, Karen M. (Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ...