Browsing Physiology by Author "Clinical and Translational Research Scholars Programme, Molecular Medicine Ireland"

Now showing items 1-2 of 2

    • Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression 

      Fitzgibbon, Marie; Kerr, Daniel M.; Henry, Rebecca J.; Finn, David P.; Roche, Michelle (Elsevier, 2019-09-07)
      Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ...

    • Ulk4 regulates GABAergic signaling and anxiety-related behavior 

      Liu, Min; Fitzgibbon, Marie; Wang, Yanqin; Reilly, Jamie; Qian, Xiaohong; O’Brien, Timothy; Clapcote, Steve; Shen, Sanbing; Roche, Michelle (Springer Nature, 2018-02-02)
      Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...