Browsing College of Engineering and Informatics by Author "Deshpande, Vikram S."
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Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
Ronan, William; Deshpande, Vikram S.; McMeeking, Robert M.; McGarry, J. Patrick (Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
Ronan, William; McMeeking, Robert M.; Chen, Christopher S.; Deshpande, Vikram S. (Elsevier, 2014-11-27)We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
Dowling, Enda P.; Ronan, William; Ofek, Gidon; Deshpande, Vikram S.; McMeeking, Robert M.; Athanasiou, Kyriacos A. (The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
The tensile ductility of cellular solids: the role of imperfections
Ronan, William; Deshpande, Vikram S.; Fleck, Norman A. (Elsevier, 2016-10-11)Metallic and polymeric foams typically possess a low tensile failure strain of a few percent despite the fact that the parent solid can have high ductility (10% or more). This is remarkable as foams are bending-dominated ...