Browsing by Author "van Sluis, Marjolein"
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A localized nucleolar dna damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage
van Sluis, Marjolein; McStay, Brian (Cold Spring Harbor Laboratory, 2015-05-27)DNA double-strand breaks (DSBs) are repaired by two main pathways: nonhomologous end-joining and homologous recombination (HR). Repair pathway choice is thought to be determined by cell cycle timing and chromatin context. ... -
Dna repair: location, location, location
van Sluis, Marjolein; McStay, Brian (Impact Journals, LLC, 2015-07-10) -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
van Sluis, Marjolein (2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ...