Browsing by Subject "irradiation"
Now showing items 1-5 of 5
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Hematopoietic stem cell quiescence promotes error-prone dna repair and mutagenesis
(Elsevier BV, 2010-08-01)Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes ... -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
(Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Multiple facets of the dna damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines
(Wiley-Blackwell, 2012-12-19)The regeneration of the hematopoietic system following total body irradiation is supported by host-derived mesenchymal stromal cells (MSCs) within the bone marrow. The mechanisms used by MSCs to survive radiation doses ... -
Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells
(Public Library of Science (PLoS), 2015-04-02)While human mesenchymal stem cells (hMSCs), either in the bone marrow or in tumour microenvironment could be targeted by radiotherapy, their response is poorly understood. The oxic effects on radiosensitivity, cell cycle ... -
Simulated sunlight inactivation of norovirus and frna bacteriophage in seawater
(Wiley-Blackwell, 2013-07-02)Aims: To investigate norovirus (NoV) and F-specific RNA (FRNA) bacteriophage inactivation in seawater under simulated sunlight and temperature conditions representative of summer (235Wm(-2); 17 degrees C) and winter ...