Browsing by Subject "apoptosis"
Now showing items 1-20 of 76
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2-alkynoic fatty acids inhibit topoisomerase ib from leishmania donovani
(Elsevier BV, 2012-10-01) -
A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling
(Elsevier BV, 2014-04-01)Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ... -
A heat shock protein and wnt signaling crosstalk during axial patterning and stem cell proliferation
(Elsevier BV, 2012-02-01) -
A lifetime of stress: atf6 in development and homeostasis
(Springer Nature, 2018-05-25)Background: Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked ... -
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ... -
Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation
(American Physiological Society, 2002-12-01)Although hydrogen peroxide (H2O2) induces proliferation of vascular smooth muscle cells, its role in endothelial cell proliferation is unclear. Our aim was to study the role of hydrogen peroxide in endothelial cell ... -
Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
(Oxford University Press (OUP), 2008-03-01)The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest ... -
Antioxidant-mediated inhibition of the heat shock response leads to apoptosis
(Wiley-Blackwell, 1999-02-19) -
Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations
(Frontiers Media SA, 2012-01-01)Programmed cell death (PCD) is an essential cellular mechanism that is evolutionary conserved, mediated through various pathways and acts by integrating different stimuli. Many diseases such as neurodegenerative diseases ... -
Carvacrol inhibits osteoclastogenesis and negatively regulates the survival of mature osteoclasts
(Pharmaceutical Society of Japan, 2016-01-01)Bone is a dynamic tissue that undergoes continuous remodeling coupled with the action of osteoblasts and osteoclasts. Osteoclast activity is elevated during osteoporosis and periodontitis resulting in excessive loss of ... -
Caspases as therapeutic targets
(Wiley-Blackwell, 2008-09-01)The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ... -
Co-acting gene networks predict trail responsiveness of tumour cells with high accuracy
(Springer Nature, 2014-01-01)Background: Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction ... -
Cytokine-induced β-cell apoptosis is no-dependent, mitochondria-mediated and inhibited by bcl-xl
(Wiley-Blackwell, 2008-04-01)Pro-inflammatory cytokines are implicated as the main mediators of beta-cell death during type 1 diabetes but the exact mechanisms remain unknown. This study examined the effects of interleukin-1 beta (IL-1 beta), ... -
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under er stress conditions
(Informa UK Limited, 2014-11-02)Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and ... -
Delivery of strail variants by mscs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects
(Springer Nature, 2013-02-01)Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related ... -
Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines
(Springer Nature, 2009-04-07)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ... -
Distinct mechanisms underlie oral vs aboral regeneration in the cnidarianhydractinia echinata
(eLife Sciences Organisation, Ltd., 2015-04-17)Cnidarians possess remarkable powers of regeneration, but the cellular and molecular mechanisms underlying this capability are unclear. Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation ... -
Dna-pk activity is associated with caspase-dependent myogenic differentiation
(Wiley-Blackwell, 2016-10-01)Differentiation of myoblasts into myotubes is essential for skeletal muscle development and regeneration. Caspase-3 and caspase-9 are required for efficient myoblast differentiation. The caspase-activated endonuclease ... -
Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
(Wiley-Blackwell, 2005-07-01)Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ... -
Dr4 specific trail variants are more efficacious than wild-type trail in pancreatic cancer
(Informa UK Limited, 2014-11-20)Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since ...