Browsing by Author "Ryder, Alan G."
Now showing items 1-20 of 98
-
A comparative study of the use of powder x-ray diffraction, raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam
Croker, Denise M.; Hennigan, Michelle C.; Maher, Anthony; Hu, Yun; Ryder, Alan G.; Hodnett, Benjamin K. (Elsevier BV, 2012-04-01) -
A family of [ni8] cages templated by μ6-peroxide from dioxygen activation
Perivolaris, Alexandros; Stoumpos, Constantinos C.; Karpinska, Jolanta; Ryder, Alan G.; Frost, Jamie M.; Mason, Kevin; Prescimone, Alessandro; Slawin, Alexandra M. Z.; Kessler, Vadim G.; Mathieson, Jennifer S.; Cronin, Leroy; Brechin, Euan K.; Papaefstathiou, Giannis S. (Royal Society of Chemistry (RSC), 2014-01-01)A family of exceptionally thermally stable [Ni-8] cages is reported, each being templated by a rare eta(3):eta(3):mu(6)-O-2(2-) species produced by dioxygen activation, where the reducing agent for the O-2 reduction appears ... -
A fluorescence anisotropy method for measuring protein concentration in complex cell culture media
Groza, Radu Constantin; Calvet, Amandine; Ryder, Alan G. (Elsevier BV, 2014-04-01) -
Accurate anisotropy recovery from fluorophore mixtures using Multivariate Curve Resolution (MCR)
Casamayou-Boucau, Yannick; Ryder, Alan G. (Elsevier, 2017-11-22)Anisotropy resolved multidimensional emission spectroscopy (ARMES) provides valuable insights into multi-fluorophore systems like proteins that have complex overlapping emission bands. The method combines multidimensional ... -
An improved genetic programming technique for the classification of raman spectra
Hennessy, Kenneth; Madden, Michael G.; Conroy, Jennifer; Ryder, Alan G. (Elsevier BV, 2005-08-01) -
Analysis of crude petroleum oils using fluorescence spectroscopy.
Ryder, Alan G. (Springer, 2005)Crude oil is defined as a mixture of hydrocarbons that existed in the liquid phase in natural underground reservoirs and remains liquid at atmospheric pressure after passing through surface separating facilities (joint ... -
Analysis of hydrocarbon bearing fluid inclusions HCFI) using time-resolved fluorescence spectroscopy
Przyjalgowski, Milosz A.; Ryder, Alan G.; Feely, Martin; Glynn, Thomas J. (Society of Photo-optical Instrumentation Engineers, 2005)Hydrocarbon-bearing fluid inclusions (HCFI) are microscopic cavities within rocks that are filled with petroleum oil, the composition of which may not have changed since the trapping event. Thus, the composition of that ... -
Analyzing protein conjugation reactions for antibody-drug conjugate synthesis using polarized excitation emission matrix spectroscopy
de Faria e Silva, Ana L.; Ryder, Alan G. (Wiley, 2022-09-07)Antibody-drug conjugates (ADCs) are promising anticancer therapeutics, which offer important advantages compared to more classical therapies. There are a variety of ADC critical quality attributes (CQAs) such as the protein ... -
Anisotropy resolved multi-dimensional emission spectroscopy (ARMES): a new tool for the quantitative and structural analysis of proteins
Groza, Radu Constantin (NUI Galway, 2016-03-24)The quantitative and structural analysis of proteins is of great importance in numerous fields (from industrial to academic research). Requirements like ease of analysis, sample handling, robustness, analysis time, the ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
Casamayou-Boucau, Yannick (NUI Galway, 2018-11-14)Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) for the analysis of Immunoglobulin G (IgG) type proteins
Steiner-Browne, Marina (NUI Galway, 2020-10-02)Immunoglobulin G (IgG) is the main antibody used in the biopharmaceutical industry for therapeutic purposes. Monoclonal antibodies (mAb) are growing in the marked due to its high specificity and safety. Physical and ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES): A new tool for protein analysis
Groza, Radu Constantin; Ryder, Alan G.; Li, Boyan (Elsevier, 2015-07-30)Structural analysis of proteins using the emission of intrinsic fluorophores is complicated by spectral overlap. Anisotropy resolved multidimensional emission spectroscopy (ARMES) overcame the overlap problem by the use ... -
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
Buckley, Kevin; Ryder, Alan G. (Sage Publications, 2017-05-23)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ... -
Applications of raman spectroscopy in biopharmaceutical manufacturing: a short review
Buckley, Kevin; Ryder, Alan G. (SAGE Publications, 2017-05-23)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ... -
Assessing protein–surface interactions with a series of multi-labeled bsa using fluorescence lifetime microscopy and förster energy resonance transfer
Togashi, Denisio M.; Ryder, Alan G. (Elsevier BV, 2010-11-01) -
Bioprocess monitoring using Polarised Multidimensional Fluorescence (pMDF) spectroscopy
Boateng, Bernard Owusu (NUI Galway, 2022-06-15)Bioprocess monitoring is essential for biopharmaceutical manufacturing as it helps to ensure the required quality of the therapeutic proteins and maximise the productivity of the bioprocess as per Quality-by-Design (QbD) ... -
Calibration, standardization, and quantitative analysis of multidimensional fluorescence (MDF) measurements on complex mixtures (IUPAC Technical Report)
Ryder, Alan G.; Stedmon, Colin A.; Harrit, Niels; Bro, Rasmus (De Gruyter, 2017-11-15)This IUPAC Technical Report describes and compares the currently applied methods for the calibration and standardization of multi-dimensional fluorescence (MDF) spectroscopy data as well as recommendations on the correct ... -
Cell culture media analysis using rapid spectroscopic methods
Ryder, Alan G. (Elsevier, 2018-09-24)Cell culture media (CCM) used in industrial biotechnology are complex mixtures of molecules and elements that are inherently difficult to analyze comprehensively. CCM quality analysis is of utmost importance for efficient ... -
Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy
Broderick, Ronan; Ramadurai, Sivaramakrishnan; Tóth, Katalin; Togashi, Denisio M.; Ryder, Alan G.; Langowski, Jörg; Nasheuer, Heinz-Peter (Public Library of Science, 2012-04-19)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ... -
Cell cycle-dependent mobility of Cdc45 in living cells determined by fluorescence correlation spectroscopy.
Broderick, Ronan; Ramadurai, Sivaramakrishnan; Togashi, Denisio M.; Ryder, Alan G.; Langowski, Jorg (Public Library of Science, 2012)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ...