Browsing by Author "Rooney, Gemma E."
Now showing items 1-7 of 7
-
Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord
Madigan, Nicolas N.; Chen, Bingkun K.; Knight, Andrew M.; Rooney, Gemma E.; Sweeney, Eva; Kinnavane, Lisa; Yaszemski, Michael J.; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S.; Windebank, Anthony J. (Mary Ann Liebert, 2014-08-08)The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as a deconstructed model that allows for control of individual variables and direct observation of their effects on regeneration. ... -
Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ... -
Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord
Donnelly, Eleanor M.; Madigan, Nicolas N.; Rooney, Gemma E.; Knight, Andrew; Chen, Bingkun; Ball, Bret; Kinnavane, Lisa; Garcia, Yolanda; Dockery, Peter; Fraher, John; Strappe, Padraig M.; Windebank, Anthony J.; O'Brien, Timothy; McMahon, Siobhan S. (Elsevier, 2012-01-08)Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ... -
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
Donnelly, Eleanor M.; Strappe, Padraig M.; McGinley, Lisa M.; Madigan, Nicolas N.; Geurts, Elizabeth; Rooney, Gemma E.; Windebank, Anthony J.; Fraher, John; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S. (Wiley, 2010)Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ... -
Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells
Rooney, Gemma E.; McMahon, Siobhan; Ritter, Thomas; Garcia, Yolanda; Moran, Cathal; Madigan, Nicholas N. (Mary Ann Liebert, 2009-10)The aim of this study was to assess the feasibility of transplanting mesenchymal stem cells (MSCs), genetically modified to express glial-derived neurotrophic factor (GDNF), to the contused rat spinal cord, and to subsequently ... -
Sustained delivery of dibutyryl cyclic adenosine monophosphate to the transected spinal cord via oligo [(polyethylene glycol) fumarate] hydrogels
Rooney, Gemma E.; Knight, Andrew M.; Madigan, Nicolas N.; Gross, LouAnn; Chen, BingKun; Giraldo, Catalina Vallejo; Seo, Seungmae; Nesbitt, Jarred J.; Dadsetan, Mahrokh; Yaszemski, Michael J.; Windebank, Anthony J. (Mary Ann Liebert Inc, 2011-05-01)This study describes the use of oligo [(polyethylene glycol) fumarate] (OPF) hydrogel scaffolds as vehicles for sustained delivery of dibutyryl cyclic adenosine monophosphate (dbcAMP) to the transected spinal cord. dbcAMP ...