Browsing by Subject "Physiology"
Now showing items 1-20 of 20
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6-iodonordihydrocapsaicin
(2009)6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Changing diet and physical activity behaviour in type 2 diabetes
(NUI Galway, 2022-03-14)The aim of this thesis was to design an artefact to support diet and physical activity behaviour change in people with type 2 diabetes. The first step was to identify behaviour change techniques (BCTs) in diet and physical ... -
Circuitry underlying regulation of the serotonergic system by swim stress
(Society for Neuroscience, 2003-02-01)The dorsal raphe nucleus (DR)–serotonin (5-HT) system has been implicated in depression and is dramatically affected by swim stress, an animal model with predictive value for antidepressants. Accumulating evidence implicates ... -
Elastin-based hydrogel as a treatment for critical limb ischemia, an insight into the glyco-host response
(NUI Galway, 2019-10-01)Critical limb ischemia (CLI) is severe impairment of the microcirculation resulting in inflammation, ischaemic pain, non-healing ulcers and gangrene. Over 20% of patients have no option but to undergo a major limb amputation. ... -
Endocannabinoid modulation of TLR3-induced neuroinflammation
(2017-10-06)Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ... -
Endocannabinoid regulation of neuroinflammatory responses following acute systemic viral (TLR3) and bacterial (TLR4) infection
(2015-10-14)Toll like receptors (TLRs) are key players in host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation has been proposed to trigger the onset of certain neurodegenerative disorders ... -
In vitro model development for pulsed-field ablation treatment of atrial fibrillation
(NUI Galway, 2024-04-15)Atrial fibrillation is the most common type of cardiac arrhythmias in humans, mostly based on hyperexcitation of specific areas in the atrium that results in dyssynchronous atrial contraction, leading to severe ... -
Involvement of toll-like receptor 4 in concanavalin A-induced liver injury: Investigation on structure and permeability of intestinal wall
(NUI Galway, 2021-08-31)Concanavalin A (ConA) induces T cell-mediated liver injury in mice associated with altered microcirculation, cytokine signalling cascades, and increased intestinal permeability. Toll-like receptor 4 (TLR4) acts as a sensor ... -
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
(Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ... -
Neuroinflammatory mechanisms linking pain and depression
(Karger, 2015)Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ... -
Prostaglandin Transport in the Bovine Uterus
(2011-10-20)Abstract In the present study, the effect of bovine oestrous cycle stages and rat oestrous cycle stages were investigated for the expression of PGT protein in uterine tissue, while isolated BUECs were also examined to ... -
Role of LPS/TLR4 and complement signaling in liver regeneration after partial hepatectomy
(NUI Galway, 2018-04-25)Liver regeneration after partial hepatectomy (PH) is a complex process involving an inflammatory response that is followed by the proliferation of both parenchymal and nonparenchymal liver cells to restore the lost liver ... -
The role of microRNAs in muscle wasting during ageing and disease
(NUI Galway, 2023-05-23)Sarcopenia is age-related muscle loss and management is complex. The mechanisms underpinning age-related decline in muscle health include defective muscle regeneration and deterioration of neuromuscular junctions. ... -
The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
(NUI Galway, 2020-10-20)Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ... -
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
(NUI Galway, 2019-11-11)Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ... -
Stress-induced exacerbation of LPS/GalN liver injury
(NUI Galway, 2018-08-21)Stress is a key regulator of homeostasis in the body. However, aberrant activation of the stress response has been implicated in predisposing to, and exacerbating processes that underlie a variety of pathological conditions ... -
Therapeutic targets for duchenne muscular dystrophy
(NUI Galway, 2019-07-05)Duchenne Muscular Dystrophy (DMD) is a progressive X-linked fatal muscle degenerative disorder caused by the absence of the sarcolemmal associated dystrophin-glycoprotein complex (DGC) that connects the intracellular ... -
The use of neuromuscular electrical stimulation (NMES) as part of the postoperative care regime in orthopaedic patients
(2017-09-14)Total Knee Arthroplasty (TKA) is an extremely beneficial procedure carried out primarily as a treatment for end-stage knee osteoarthritis to improve both quality of life and physical functioning. Limitations in physical ... -
Vascular plasticity and target for therapy in Duchenne muscular dystrophy
(NUI Galway, 2023-06-13)Angiogenesis is the growth of new blood vessels from pre-existing vessels, necessary for the growth and maintenance of homeostasis. Duchenne muscular dystrophy (DMD) is a debilitating disease of the musculoskeletal ...