Browsing by Subject "Pharmacology"
Now showing items 1-16 of 16
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Assessment of the consequences of gestational SSRI antidepressant exposure in the rat
(NUI Galway, 2019-10-08)Although the most common psychotropic drugs prescribed in pregnancy are selective serotonin reuptake inhibitor (SSRI) antidepressants, their health impact on the resultant offspring is largely unknown due to the ethical ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
(2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ... -
Development and characterisation of a novel preclinical test battery for detecting anxiolytic and antidepressant properties of drugs
(2016-10-19)Depression is a chronic, recurring and potentially life-threatening disorder that is highly comorbid with anxiety. The aetiology of depression, anxiety and their comorbidity is still largely unknown. Despite the development ... -
Inflammatory-environment interactions as an approach to modelling Parkinson's disease
(2017-09-22)It has been over 50 years since the first demonstration that levodopa was capable of reversing the motor dysfunction associated with Parkinson’s disease. In the intervening decades, although levodopa has remained the most ... -
Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells
(2010)6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, ... -
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
Methamphetamine exposure during pregnancy: Neurodevelopmental consequences for the offspring
(2016-04-05)Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ... -
Mitochondrial pathway of apoptosis controls muscle differentiation
(NUI Galway, 2020-09-01)Caspases are the core compartments of programmed cell death. Caspases also play non apoptotic roles in cell proliferation, migration, differentiation, and immunity. During myoblast differentiation, caspase-2, -9 and -3 are ... -
Modelling early life exposure to antidepressants in rats: Developmental, behavioural and neurochemical aspects
(2013-02-11)Depression during pregnancy and the postpartum period has been associated with deleterious consequences such as preterm birth, low birth weight and less optimal scores on neonatal reflexes and behaviour. Pharmacological ... -
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ... -
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ... -
The role of the endocannabinoid system in the affective modulation of pain
(2015-09-30)Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ... -
Subtotal ablation and hyperthermia in the adrenal cortex
(NUI Galway, 2021-08)Primary aldosteronism (PA) accounts for 5–12% of all hypertension and confers a higher risk for cardiovascular and cerebrovascular complications compared to age and blood pressure (BP) matched essential hypertension. PA ...