Browsing by Subject "Macromolecular crowding"
Now showing items 1-8 of 8
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Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture
(Elsevier Academic Press, 2019-11-30)Tendon injuries continuously rise, and regeneration is not only slow, but also limited due to the poor endogenous healing ability of the tendon tissue. Tissue grafts constitute the clinical gold standard treatment for ... -
Macromolecular crowding meets tissue engineering by self-assembly
(2015-01-29)Introduction: Advancements in molecular and cell biology have led to the development of tissue engineering by self-assembly. The driving hypothesis of this concept is that replacement, repair and restoration of lost tissue ... -
Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional tissue moduli
(NUI Galway, 2020-11-04)Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, traditional cell-assembled tissue ... -
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
(Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Preparation and characterization of tissue surrogates rich in extracellular matrix using the principles of macromolecular crowding
(Humana Press, 2019-03)Tissue engineering by self-assembly allows for the fabrication of living tissue surrogates by taking advantage of the cell's inherent ability to produce and deposit tissue-specific extracellular matrix. However, the long ... -
Replicating and modulating skin fibrosis in vitro: Multi-compartment collagen devices as dual drug delivery vehicles
(NUI Galway, 2022-01-10)Complex pathologies, such as fibrosis, are often not the result of a singular event, but rather the consequence of multiple disruptions in the normal balance between intricately connected organs, tissues and signalling ...