Browsing by Author "Laffey, John G"
Now showing items 1-16 of 16
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O' Croinin, Donall; Ni Chonghaile, Martina; Higgins, Brendan; Laffey, John G (Springer Nature, 2004-01-01)Current protective lung ventilation strategies commonly involve hypercapnia. This approach has resulted in an increase in the clinical acceptability of elevated carbon dioxide tension, with hypoventilation and hypercapnia ... -
Bench-to-bedside review: carbon dioxide
Curley, Gerard; Laffey, John G; Kavanagh, Brian P (Springer Nature, 2010-01-01)Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO(2) represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common and generally ... -
Can 'permissive' hypercapnia modulate the severity of sepsis-induced ali/ards?
Curley, Gerard; Hayes, Mairead; Laffey, John G (Springer Nature, 2011-01-01) -
Clinical review: gene-based therapies for ali/ards: where are we now?
Devaney, James; Contreras, Maya; Laffey, John G (Springer Nature, 2011-01-01)Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) confer substantial morbidity and mortality, and have no specific therapy. The accessibility of the distal lung epithelium via the airway route, and the ... -
Clinical review: special populations - critical illness and pregnancy
Neligan, Patrick J; Laffey, John G (Springer Nature, 2011-01-01)Critical illness is an uncommon but potentially devastating complication of pregnancy. The majority of pregnancy-related critical care admissions occur postpartum. Antenatally, the pregnant patient is more likely to be ... -
Clinical review: stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?
Hayes, Mairead; Curley, Gerard; Ansari, Bilal; Laffey, John G (Springer Nature, 2012-01-01)A growing understanding of the complexity of the pathophysiology of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), coupled with advances in stem cell biology, has led to a renewed interest in the ... -
Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study
McDonnell, Melissa J; Aliberti, Stefano; Goeminne, Pieter C; Restrepo, Marcos I; Finch, Simon; Pesci, Alberto; Dupont, Lieven J; Fardon, Thomas C; Wilson, Robert; Loebinger, Michael R; Skrbic, Dusan; Obradovic, Dusanka; De Soyza, Anthony; Ward, Chris; Laffey, John G; Rutherford, Robert M; Chalmers, James D (Elsevier BV, 2016-12-01)Background Patients with bronchiectasis often have concurrent comorbidities, but the nature, prevalence, and impact of these comorbidities on disease severity and outcome are poorly understood. We aimed to investigate ... -
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Maharaj, Chrisen H; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D; Morrison, John J; Laffey, John G (Springer Nature, 2009-01-01)Objectives: Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ... -
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the lung safe prospective cohort study
Laffey, John G; Madotto, Fabiana; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Brochard, Laurent; Amin, Pravin; Arabi, Yaseen; Bajwa, Ednan K; Bruhn, Alejandro; Cerny, Vladimir; Clarkson, Kevin; Heunks, Leo; Kurahashi, Kiyoyasu; Laake, Jon Henrik; Lorente, Jose A; McNamee, Lia; Nin, Nicolas; Palo, Jose Emmanuel; Piquilloud, Lise; Qiu, Haibo; Jiménez, Juan Ignacio Silesky; Esteban, Andres; McAuley, Daniel F; van Haren, Frank; Ranieri, Marco; Rubenfeld, Gordon; Wrigge, Hermann; Slutsky, Arthur S; Pesenti, Antonio (Elsevier BV, 2017-08-01)Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of ... -
Hydroxymethylglutaryl-coa reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (harp-2) trial: study protocol for a randomized controlled trial
McAuley, Daniel F; ,; Laffey, John G; O’Kane, Cecilia M; Cross, Mark; Perkins, Gavin D; Murphy, Lynn; McNally, Christine; Crealey, Grainne; Stevenson, Michael (Springer Nature, 2012-09-17)Background: Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure. There are in vitro, animal ... -
Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury
Kennedy, Muiris T; Higgins, Brendan D; Costello, Joseph F; Curtin, William A; Laffey, John G (BioMed Central Ltd., 2008-07-08)Background: Hypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung ... -
Inhibition of pulmonary nuclear factor kappa-b decreases the severity of acute escherichia coli pneumonia but worsens prolonged pneumonia
Devaney, James; Curley, Gerard F; Hayes, Mairead; Masterson, Claire; Ansari, Bilal; O'Brien, Timothy; O'Toole, Daniel; Laffey, John G (Springer Nature, 2013-01-01)Introduction: Nuclear factor (NF)-kappa B is central to the pathogenesis of inflammation in acute lung injury, but also to inflammation resolution and repair. We wished to determine whether overexpression of the NF-kappa ... -
Investigation of the mechanisms of repair following Ventilator Induced Lung Injury and the potential for Mesenchymal Stem Cells to enhance the repair process
Curley, Gerard (2012-02-10)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Virtually all patients with ARDS receive mechanical ... -
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
Contreras, Maya (2012-11)Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ... -
Lung stem cells - from an evolving understanding to a paradigm shift?
Hayes, Mairéad; Curley, Gerard F; Laffey, John G (Springer Nature, 2011-01-01)The ideal cell type to regenerate an acutely injured or chronically diseased lung would be a stem cell population from the patient's own lung. Consequently, extensive research efforts have focused on identifying and ... -
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
Curley, Gerard F; Hayes, Mairead; Ansari, Bilal; Shaw, Georgina; Ryan, Aideen; Barry, Frank; O'Brien, Timothy; O'Toole, Daniel; Laffey, John G (BMJ, 2011-11-21)Background Bone-marrow derived mesenchymal stem cells (MSCs) reduce the severity of evolving acute lung injury (ALI), but their ability to repair the injured lung is not clear. A study was undertaken to determine the ...