Browsing by Author "Health Research Board"
Now showing items 1-15 of 15
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Antimicrobial prescribing and resistance in Irish general practice
Vellinga, Akke (2011-04-20)The emerging problem of antimicrobial resistance in bacterial pathogens is complex and the result of individual and population factors. Antimicrobial agents are unique therapeutics in that their impact goes beyond the ... -
Atrial fibrillation and stroke: natural history, risk factors and clinical consequences
McGrath, Emer (2013-08-28)Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. ... -
Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences
McGrath, E (2013-08-28)Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. ... -
Economic Essays on Burden, Survivorship and Health Literacy - A Focus on HPV-Related Head and Neck Cancer
Coughlan, James Diarmuid (2014-09-20)Our understanding of cancer and the role of specific agents in its cause continues to evolve. Head and Neck Cancers (HNC) in the developed world were traditionally associated with excessive smoking and drinking. Since 2000, ... -
An economic examination of cancer screening
Walsh, Brendan (2014-05-30)A substantial burden is borne by individuals and societies from cancer. Cancer control strategies are implemented to reduce this burden and cancer screening is a central facet within cancer control strategies. Cancer ... -
Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial.
Murphy, Andrew W.; Byrne, Molly; Newell, John (2009)Objective To test the effectiveness of a complex intervention designed, within a theoretical framework, to improve outcomes for patients with coronary heart disease. Design Cluster randomised controlled multicentre trial. ... -
Evaluating the economic impacts and cost-effectiveness of PSA testing for the secondary prevention of prostate cancer in the Republic of Ireland
Burns, Richéal (2015-12-18)Prostate cancer (PCa) incidence, internationally, has steadily increased since the latter half of the twentieth century as with the prevalence of other cancers. (Jemel et al, 2008; Jemel et al, 2011) It is recognised that ... -
Exploring and enhancing autonomy for older people in residential care
Welford, Claire Lisa (2012-10-25)The purpose of this study was to explore autonomy for older people in residential care. A single exploratory embedded case study design was used. The case study was adopted for the purpose of gaining a better understanding ... -
Exploring inequalities in service use: the case of cervical cancer screening in Ireland, the United Kingdom and United States
Walsh, Brendan; O'Neill, Stephen; O'Neill, Ciaran (National University of Ireland, Galway, 2013)This study examined inequalities in uptake of cervical cancer screening in the Republic of Ireland, Britain and Northern Ireland, and the United States using data from nationally representative surveys in 2007/2008. ... -
Intra-Renal Inflammation in Obesity and Type 2 Diabetes Mellitus
McNicholas, Bairbre Aine (2013-09-30)Introduction: Unhealthy diet and sedentary lifestyle, lead to the constellation of obesity, hyperinsulinaemia and hyperlipidaemia that are risk factors for both chronic kidney disease and type 2 Diabetes mellitus. Renal ... -
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ... -
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ... -
Responses to language barriers in consultations with refugees and asylum seekers: a telephone survey of Irish general practitioners
MacFarlane, Anne; Glynn, Liam G.; Mosinkie, Phillip I.; Murphy, Andrew W. (BioMed Central, 2008)Background: Refugees and asylum seekers experience language barriers in general practice. Qualitative studies have found that responses to language barriers in general practice are ad hoc with use of both professional ... -
Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts
Mahon, Cathal; Tikhanovich, Irina; Nasheuer, Heinz P. (2009)BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ... -
Site-directed mapping of nucleosome structure and dynamics in vitro
Doran, Jonathan (2013-03-04)The nucleosome core particle is the most basic unit of chromatin packaging. It is composed of an octamer of two each of the histone proteins H2A, H2B, H3 and H4 wrapped in ~147 bp of DNA. Nucleosome positioning and sliding ...