Browsing by Subject "Epigenetics"
Now showing items 1-9 of 9
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Centromere function in asymmetrically dividing Drosophila germline stem cells
(NUI Galway, 2023-03-28)Germline stem cells (GSCs) undergo asymmetric cell division (ACD) to give rise to one stem cell residing in the niche and one differentiating daughter cell. The daughter cell subsequently divides through mitosis and meiosis ... -
DNA mediated chromatin pull-down for the study of chromatin replication
(2011)Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. Here we describe a simple experimental ... -
DNA mediated chromatin pull-down: a novel method for the study of chromatin replication
(2012-04-27)Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. To investigate how these processes are ... -
Epigenetic regulation of germline stem cell fate by Centromere Protein C
(NUI Galway, 2021-01-21)Germline stem cells (GSCs) divide asymmetrically to produce one new daughter stem cell and one daughter cell that will subsequently undergo meiosis and differentiate to generate the mature gamete. The ‘silent sister ... -
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ... -
Genetic diversity, evolutionary history and epigenetic analysis of East African highland bananas
(2015-05-13)Genetic variation describes naturally occurring genetic differences among individuals of the same species and permits flexibility and survival of a population in the face of changing environmental circumstances, diseases ... -
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ... -
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ... -
Novel insights into the molecular roles of UBP5 in controlling chromatin dynamics and plant development
(NUI Galway, 2023-04-03)Polycomb group (PcG) proteins are conserved chromatin regulators essential for controlling key developmental programs in eukaryotes. PcG proteins assemble together to form multi-protein complexes known as Polycomb ...