Browsing by Author "Cosgrove, Donna"

Now showing items 1-6 of 6

    • Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression 

      Whitton, Laura; Cosgrove, Donna; Clarkson, Christopher; Harold, Denise; Kendall, Kimberley; Richards, Alex; Mantripragada, Kiran; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Hartmann, Annette; Konte, Betina; Rujescu, Dan; Gill, Michael; Corvin, Aiden; Rea, Stephen; Donohoe, Gary; Morris, Derek W. (Wiley, 2016-10-20)
      Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, and synaptic plasticity. These ...

    • Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of cacna1c's role in working memory 

      Cosgrove, Donna; Mothersill, Omar; Kendall, Kimberley; Konte, Bettina; Harold, Denise; Giegling, Ina; Hartmann, Annette; Richards, Alex; Mantripragada, Kiran; Owen, Michael J; O’Donovan, Michael C; Gill, Michael; Rujescu, Dan; Walters, James; Corvin, Aiden; Morris, Derek W.; Donohoe, Gary (Springer Nature, 2017-06-13)
      With 4100 common variants associated with schizophrenia risk, establishing their biological significance is a priority. We sought to establish cognitive effects of risk variants at loci implicated in synaptic transmission ...

    • Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons 

      Cosgrove, Donna; Whitton, Laura; Fahey, Laura; Ó Broin, Pilib; Donohoe, Gary; Morris, Derek W. (Oxford University Press (OUP), 2020-09-25)
      Myocyte enhancer factor 2 C (MEF2C) is an important transcription factor during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within MEF2C are associated with ...

    • Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation 

      Donohoe, Gary; Holland, Jessica; Mothersill, David; McCarthy Jones, Simon; Cosgrove, Donna; Harold, Denise; Richards, Alex; Mantripragada, Kiran; Owen, Michael J.; O’Donovan, Michael C.; Gill, Michael; Corvin, Aiden; Morris, Derek W. (Cambridge University Press, 2018-01-09)
      Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component ...

    • Neurocognitive effects of risk variants for psychosis: neuropsychological and neuroimaging studies of variants and pathways 

      Cosgrove, Donna (2017-07-19)
      Schizophrenia is a complex, highly polygenic brain disorder. Cognitive deficits in schizophrenia are among the most disabling symptoms, and as of yet, have no effective treatment. Investigating the effect of genetic variants ...

    • The genetics of endophenotypes of neurofunction to understand schizophrenia (genus) consortium: a collaborative cognitive and neuroimaging genetics project 

      Blokland, Gabriëlla A.M.; del Re, Elisabetta C.; Mesholam-Gately, Raquelle I.; Jovicich, Jorge; Trampush, Joey W.; Keshavan, Matcheri S.; DeLisi, Lynn E.; Walters, James T.R.; Turner, Jessica A.; Malhotra, Anil K.; Lencz, Todd; Shenton, Martha E.; Voineskos, Aristotle N.; Rujescu, Dan; Giegling, Ina; Kahn, René S.; Roffman, Joshua L.; Holt, Daphne J.; Ehrlich, Stefan; Kikinis, Zora; Dazzan, Paola; Murray, Robin M.; Di Forti, Marta; Lee, Jimmy; Sim, Kang; Lam, Max; Wolthusen, Rick P.F.; de Zwarte, Sonja M.C.; Walton, Esther; Cosgrove, Donna; Kelly, Sinead; Maleki, Nasim; Osiecki, Lisa; Picchioni, Marco M.; Bramon, Elvira; Russo, Manuela; David, Anthony S.; Mondelli, Valeria; Reinders, Antje A.T.S.; Falcone, M. Aurora; Hartmann, Annette M.; Konte, Bettina; Morris, Derek W.; Gill, Michael; Corvin, Aiden P.; Cahn, Wiepke; Ho, New Fei; Liu, Jian Jun; Keefe, Richard S.E.; Gollub, Randy L.; Manoach, Dara S.; Calhoun, Vince D.; Schulz, S. Charles; Sponheim, Scott R.; Goff, Donald C.; Buka, Stephen L.; Cherkerzian, Sara; Thermenos, Heidi W.; Kubicki, Marek; Nestor, Paul G.; Dickie, Erin W.; Vassos, Evangelos; Ciufolini, Simone; Reis Marques, Tiago; Crossley, Nicolas A.; Purcell, Shaun M.; Smoller, Jordan W.; van Haren, Neeltje E.M.; Toulopoulou, Timothea; Donohoe, Gary; Goldstein, Jill M.; Seidman, Larry J.; McCarley, Robert W.; Petryshen, Tracey L. (Elsevier BV, 2017-10-01)