Browsing by Subject "Collagen"
Now showing items 1-10 of 10
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At least three invariants are necessary to model the mechanical response of incompressible, transversely isotropic materials
(Springer, 2013-04-18)The modelling of off-axis simple tension experiments on transversely isotropic nonlinearly elastic materials is considered. A testing protocol is proposed where normal force is applied to one edge of a rectangular specimen ... -
Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit
(Elsevier, 2010-03-21)Single channel conduits are used clinically in nerve repair as an alternative to the autologous nerve graft. Axons regenerating across single channel tubes, however, may disperse resulting in inappropriate target reinnervation. ... -
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ... -
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ... -
Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels
(Elsevier, 2012-08)Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical ... -
The influence of collagen isolation, cross-linking and sterilisation on macrophage response
(2018-03-07)Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ... -
The influence of collagen type I source and cross-linking on cell function and phenotype maintenance
(NUI Galway, 2023-09-13)Collagen is a complex supramolecular structure that occurs in highly diverse morphologies across different tissues, lending them a range of physical and biological functions. Collagens have a long history in both ... -
Small–molecule reagents and building–blocks for protein materials and bioconjugation
(NUI Galway, 2023-04-18)The molecular and functional diversification conferred by posttranslational modification (PTM) of proteins is a common target and source of inspiration for chemical biologists. For example, the formylglycine-generating ... -
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
(The Royal Society Publishing, 2012-06-06)The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ... -
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
(Nature Publishing Group, 2017-10-13)Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these ...