Browsing by Subject "Checkpoint"
Now showing items 1-3 of 3
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Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
ATR mediated regulation of the abscission checkpoint
(NUI Galway, 2018-05-30)Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic material must be distributed equally between the new cells before the final abscission. Failure to complete chromosome ... -
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
(Springer, 2008)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ...