Browsing by Subject "Centromere"
Now showing items 1-8 of 8
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Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Centromere function in asymmetrically dividing Drosophila germline stem cells
(NUI Galway, 2023-03-28)Germline stem cells (GSCs) undergo asymmetric cell division (ACD) to give rise to one stem cell residing in the niche and one differentiating daughter cell. The daughter cell subsequently divides through mitosis and meiosis ... -
Epigenetic regulation of germline stem cell fate by Centromere Protein C
(NUI Galway, 2021-01-21)Germline stem cells (GSCs) divide asymmetrically to produce one new daughter stem cell and one daughter cell that will subsequently undergo meiosis and differentiate to generate the mature gamete. The ‘silent sister ... -
Functional role of CCAN histone fold proteins in mitosis
(2012-05-31)Centromeres are chromosomal loci that direct segregation of the genome by specifying kinetochore assembly in mitosis and meiosis. Kinetochores are built upon centromeric chromatin, which contains the histone H3 variant ... -
Mapping protein architecture in centromeres of Equus asinus
(2016-11-28)The centromere is a genetic locus present once per chromosome that specifies the site of kinetochore formation and is vital for chromosomal segregation. With the exception of Saccharomyces cerevisiae, whose ‘point’ ... -
Mathematical models of centromere associating proteins
(2014-07-11)This thesis describes the development and analysis of new mathematical models of Centromere Protein A (CENP-A) incorporation in mammalian centromeres, intermolecular autophosphorylation and Aurora B kinase activity in ... -
Novel functions for the CENP-A N-terminus during male meiosis in Drosophila melanogaster
(NUI Galway, 2018-03-23)Recent studies in plants and Drosophila suggest that CENP-A, the centromeric histone H3 variant and epigenetic marker of centromere localisation may have additional roles during meiosis. By immunoprecipitation and mass ... -
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
(2017-02-15)Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ...