Browsing by Subject "Amorphous"
Now showing items 1-7 of 7
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Dual-drug amorphous formulation of gliclazide
(Taylor and Francis, 2021-02-01)Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ... -
Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study
(Elsevier, 2014-04-11)The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete ... -
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ... -
Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug
(Elsevier, 2012-10-09)The formation and physical stability of amorphous sulfathiazole obtained from polymorphic forms I and III by cryomilling was investigated by X-ray powder diffraction (XRPD) and near-infrared (NIR) spectroscopy. Principal ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
(Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
(Elsevier, 2018-10-28)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ... -
Quantitative Analysis of the Amorphous Phase and Multiple Polymorphs of Model Sulfa-Drugs; Sulfamerazine and Sulfathiazole
(2013-10-30)Polymorphic transformations are known to occur as a result of many factors, one of the most prominent being recrystallisation from different solutions. Though other factors have been known to induce polymorphic change, ...