Browsing by Subject "ATM"
Now showing items 1-2 of 2
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The microprocessing factor DGCR8 interacts with ATM and functions independently of its partner DROSHA in the DDR
(NUI Galway, 2020-01-23)The eukaryotic cell has evolved a complex suite of mechanisms called the DNA damage response (DDR), that acts by sensing DNA damage and reacting appropriately to maintain genomic integrity. The PIK kinase ATM is a key ... -
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
(2017-07-05)The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ...