Browsing by Subject "stabilization"
Now showing items 1-4 of 4
-
Crystal structure of δ-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
(International Union of Crystallography (IUCr), 2000-03-01)Chymotrypsin is a member of the trypsin family of serine proteases and is one of the first proteins successfully studied by X-ray crystallography. It is secreted into the intestine as the inactive precursor chymotrypsinogen; ... -
Growth arrest-specific gene 6 expression in human breast cancer
(Springer Nature, 2008-02-19)Growth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ ... -
Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling
(American Chemical Society (ACS), 2013-01-07)The coprocessing of active pharmaceutical ingredient (API) with an excipient which has a high glass transition temperature (T-g) is a recognized strategy to stabilize the amorphous form of a drug. This work investigates ...