Browsing by Subject "primary cilium"

Now showing items 1-4 of 4

    • C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis 

      Conroy, Pauline C.; Saladino, Chiara; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G. (Informa UK Limited, 2012-10-15)
      Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ...

    • Centrobin controls primary ciliogenesis in vertebrates 

      Ogungbenro, Yetunde Adesanya; Tena, Teresa Casar; Gaboriau, David; Lalor, Pierce; Dockery, Peter; Philipp, Melanie; Morrison, Ciaran G. (Rockefeller University Press, 2018-02-13)
      The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNT ROB in hTERT-RPE1 cells and observed an increased ...

    • Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity 

      Daly, Owen M.; Gaboriau, David; Karakaya, Kadin; King, Sinéad; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Krämer, Alwin; Morrison, Ciaran G. (The Company of Biologists, 2016-03-10)
      Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ...

    • Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity 

      Breslin, Loretta; Prosser, Suzanna L; Cuffe, Sandra; Morrison, Ciaran G (Informa UK Limited, 2014-09-02)
      Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers ...