Browsing by Subject "hypermethylation"

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    • Differential dna methylation patterns of homeobox genes in proximal and distal colon epithelial cells 

      Barnicle, Alan; Seoighe, Cathal; Golden, Aaron; Greally, John M.; Egan, Laurence J. (American Physiological Society, 2016-01-26)
      Region and cell-type specific differences in the molecular make up of colon epithelial cells have been reported. Those differences may underlie the region-specific characteristics of common colon epithelial diseases such ...

    • Gene-set analysis is severely biased when applied to genome-wide methylation data 

      Geeleher, Paul; Hartnett, Lori; Egan, Laurance J.; Golden, Aaron; Raja Ali, Raja Affendi; Seoighe, Cathal (Oxford University Press (OUP), 2013-06-03)
      Motivation: DNA methylation is an epigenetic mark that can stably repress gene expression. Because of its biological and clinical significance, several methods have been developed to compare genome-wide patterns of methylation ...