Browsing by Subject "chronic lymphocytic-leukemia"

Now showing items 1-3 of 3

    • Highly sensitive b cell analysis predicts response to rituximab therapy in rheumatoid arthritis 

      Dass, Shouvik; Rawstron, Andy C.; Vital, Edward M.; Henshaw, Karen; McGonagle, Dennis; Emery, Paul (Wiley-Blackwell, 2008-10-01)
      Objective. In rheumatoid arthritis (RA), B cell depletion occurs in all patients treated with rituximab, but the clinical responses to rituximab are variable. A highly sensitive assay was used to test the hypothesis that ...

    • Mechanisms of action of a dual cdc7/cdk9 kinase inhibitor against quiescent and proliferating cll cells 

      Natoni, A.; Murillo, L. S.; Kliszczak, A. E.; Catherwood, M. A.; Montagnoli, A.; Samali, A.; O'Dwyer, M.; Santocanale, C. (American Association for Cancer Research (AACR), 2011-07-18)
      In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ...

    • Relationship between circulating and tissue micrornas in a murine model of breast cancer 

      Waters, Peadar S.; McDermott, Ailbhe M.; Wall, Deirdre; Heneghan, Helen M.; Miller, Nicola; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (Public Library of Science (PLoS), 2012-11-30)
      MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...