Browsing by Subject "chronic kidney-disease"

Now showing items 1-12 of 12

    • A secondary analysis of the choir trial shows that comorbid conditions differentially affect outcomes during anemia treatment 

      Szczech, Lynda A.; Barnhart, Huiman X.; Sapp, Shelly; Felker, G. Michael; Hernandez, Adrian; Reddan, Donal; Califf, Robert M.; Inrig, Jula K.; Patel, Uptal D.; Singh, Ajay K. (Elsevier BV, 2010-02-01)
      The CHOIR trial in anemic patients with chronic kidney disease compared epoetin-alfa treatment with low (11.3 g/l) and high (13.5 g/l) hemoglobin targets on the composite end point of death, hospitalization for heart ...

    • Blood pressure measurement in peritoneal dialysis: which method is best? 

      O'Shaughnessy, M. M.; Durcan, M.; Kinsella, S. M.; Griffin, M. D.; Reddan, D. N.; Lappin, D. W. (MultiMed Inc., 2013-04-01)
      Background: The optimal approach to monitoring blood pressure (BP) in the peritoneal dialysis (PD) population is unclear. Ambulatory BP monitoring reliably predicts prognosis, but can be inconvenient. The accuracy of home ...

    • Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease 

      Amin, Hatem K.; El-Sayed, Mohamed-I Kotb; Leheta, Ola F. (Informa UK Limited, 2016-07-19)
      Glomerular filtration rate and/or creatinine are not accurate methods for renal failure prediction. This study tested homocysteine (Hcy) as a predictive and prognostic marker for end stage renal disease (ESRD). In total, ...

    • Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of choir 

      Inrig, J. K.; Sapp, S.; Barnhart, H.; Patel, U. D.; Reddan, D.; Singh, A.; Califf, R. M.; Szczech, L. (Oxford University Press (OUP), 2012-05-09)
      Targeting a higher hemoglobin in patients with chronic kidney disease leads to adverse cardiovascular outcomes, yet the reasons remain unclear. Herein, we sought to determine whether changes in erythropoiesis-stimulating ...

    • Renal function, concomitant medication use and outcomes following acute coronary syndromes 

      Reddan, D. N.; Szczech, L.; Bhapkar, M. V.; Moliterno, D. J.; Califf, R. M.; Ohman, E. M.; Berger, P. B.; Hochman, J. S.; Van de Werf, F.; Harrington, R. A.; Newby, L. K.; , (Oxford University Press (OUP), 2005-07-19)
      Background. Chronic kidney disease (CKD) is highly prevalent in patients with cardiovascular disease. We explored the associations of CKD with outcomes using combined data from two large acute coronary syndrome (ACS) trials. ...

    • Sclerostin antibody therapy for the treatment of osteoporosis: clinical prospects and challenges 

      MacNabb, Claire; Patton, D.; Hayes, J. S. (Hindawi Limited, 2016-01-01)
      It is estimated that over 200 million adults worldwide have osteoporosis, a disease that has increasing socioeconomic impact reflected by unsustainable costs associated with disability, fracture management, hospital stays, ...

    • Secondary analysis of the choir trial epoetin-α dose and achieved hemoglobin outcomes 

      Szczech, Lynda A.; Barnhart, Huiman X.; Inrig, Jula K.; Reddan, Donal N.; Sapp, Shelly; Califf, Robert M.; Patel, Uptal D.; Singh, Ajay K. (Elsevier BV, 2008-09-01)
      Trials of anemia correction in chronic kidney disease have found either no benefit or detrimental outcomes of higher targets. We did a secondary analysis of patients with chronic kidney disease enrolled in the Correction ...

    • Sodium intake and renal outcomes: a systematic review 

      Smyth, Andrew; O’Donnell, Martin J.; Yusuf, Salim; Clase, Catherine M.; Teo, Koon K.; Canavan, Michelle; Reddan, Donal N.; Mann, Johannes F. E. (Oxford University Press (OUP), 2014-02-07)
      BACKGROUND Sodium intake is an important determinant of blood pressure; therefore, reduction of intake may be an attractive population-based target for chronic kidney disease (CKD) prevention. Most guidelines recommend ...

    • Surface glycosylation profiles of urine extracellular vesicles 

      Gerlach, Jared Q.; Krüger, Anja; Gallogly, Susan; Hanley, Shirley A.; Hogan, Marie C.; Ward, Christopher J.; Joshi, Lokesh; Griffin, Matthew D. (Public Library of Science (PLoS), 2013-09-19)
      Urinary extracellular vesicles (uEVs) are released by cells throughout the nephron and contain biomolecules from their cells of origin. Although uEV-associated proteins and RNA have been studied in detail, little information ...

    • Survival trends of us dialysis patients with heart failure: 1995 to 2005 

      Stack, A. G.; Mohammed, A.; Hanley, A.; Mutwali, A.; Nguyen, H. (American Society of Nephrology (ASN), 2011-07-22)
      Background and objectives Congestive heart failure (CHF) is a major risk factor for death in end-stage kidney disease; however, data on prevalence and survival trends are limited. The objective of this study was to determine ...

    • The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study 

      Anderson, Jocelyn; Glynn, Liam G; Newell, John; Iglesias, Alberto A; Reddan, Donal; Murphy, Andrew W (Springer Nature, 2009-11-12)
      Background: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated ...

    • Treatment of hyperkalemia with a low-dose insulin protocol is effective and results in reduced hypoglycemia 

      McNicholas, Bairbre A.; Pham, Mai H.; Carli, Katrina; Chen, Chang Huei; Colobong-Smith, Nancy; Anderson, Arthur Eric; Pham, Hien (Elsevier BV, 2017-10-01)
      Introduction: Complications associated with insulin treatment for hyperkalemia are serious and common. We hypothesize that, in chronic kidney disease (CKD) and end-stage renal disease (ESRD), giving 5 units instead of 10 ...