Browsing by Subject "chromosome condensation"
Now showing items 1-4 of 4
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Analysis of scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores
(Wiley-Blackwell, 2004-02-01)Cleavage of the cohesin subunit Scc1p/Mcd1p/Rad21 permits sister chromatid separation and is considered to trigger anaphase onset. It has also been suggested that the cohesin complex is essential for chromosome condensation ... -
Distinct brct domains in mcph1/brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
(Springer Nature, 2007-06-25)Microcephalin (MCPH1/BRIT1) forms ionizing radiation-induced nuclear foci (IRIF) and is required for DNA damage-responsive S and G(2)-M-phase checkpoints. MCPH1 contains three BRCT domains. Here we report the cloning of ... -
Mcph1/brit1 limits ionizing radiation-induced centrosome amplification
(Springer Nature, 2010-07-26)Microcephalin (MCPH1/BRIT1) is a potential tumour suppressor that localizes to the centrosome, forms ionizing radiation-induced nuclear foci (IRIF) and is involved in the DNA damage checkpoints that ensure genome stability. ... -
Modification of histones by sugar β-n-acetylglucosamine (glcnac) occurs on multiple residues, including histone h3 serine 10, and is cell cycle-regulated
(American Society for Biochemistry & Molecular Biology (ASBMB), 2011-09-06)The monosaccharide, beta-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group of either serines or threonines to generate an O-linked beta-N-acetylglucosamine (O-GlcNAc) residue (Love, D. C., and Hanover, J. ...