Browsing by Subject "Primary cilium"
Now showing items 1-5 of 5
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Centriolar and ciliary responses to DNA damage
(2012-09-26)Centrosome duplication is tightly controlled and takes place only once every cell cycle. In recent years more light has been shed on the mechanism of centrosome duplication, with key players being identified and characterised. ... -
Estrogen withdrawal in osteocytes results in altered integrin function, primary cilium elongation, and increased pro-osteoclastogenic signalling
(NUI Galway, 2020-06-28)Osteocytes are the main mechanosensitive cells within bone. They detect changes in the mechanical environment and transduce them into biochemical responses (RANKL, OPG, and sclerostin) that regulate bone remodelling by ... -
The primary cilium as a regulator of cellular senescence in human fibroblasts
(2014-02-11)Somatic cells senesce in culture after a finite number of divisions, indefinitely arresting their proliferation. Among the major causes of senescence is persistent DNA damage signalling. DNA damage and senescence increase ... -
Reverse genetic analysis of centrosomal roles of Checkpoint Kinase 1
(NUI Galway, 2019-06-14)Centrosome duplication is tightly regulated process that occurs only once per cell cycle. Centrosome abnormalities have been observed in cancer cells and in cells with defective DNA damage responses. Genotoxic stresses ... -
Understanding the multifunctional domains of controller protein Centrin2
(NUI Galway, 2018-12-21)Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics and ciliogenesis. Structurally, it has four calcium-binding EF- hand motifs. Most of the cellular centrin2 is not associated ...