Browsing by Author "Ryan, Aideen E."
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Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation
Treacy, Oliver; Ryan, Aideen E.; Heinzl, Teresa; O'Flynn, Lisa; Cregg, Marese; Wilk, Mieszko; Odoardi, Francesca; Lohan, Paul; O'Brien, Timothy; Nosov, Mikhail; Ritter, Thomas (Public Library of Science (PLoS), 2012-08-06)Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential which makes them attractive targets for regenerative medicine applications. However, to date, therapeutic success of MSC-therapy ... -
Allogeneic cell therapy for osteoarthritis
Lohan, Paul (2016-05-11)Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: Are we still learning?
Lohan, Paul; Treacy, Oliver; Griffin, Matthew D.; Ritter, Thomas; Ryan, Aideen E. (Frontiers Media, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: are we still learning?
Lohan, Paul; Treacy, Oliver; Griffin, Matthew D.; Ritter, Thomas; Ryan, Aideen E. (Frontiers Media SA, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Coexpression of nos2 and cox2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer
Basudhar, Debashree; Glynn, Sharon A.; Greer, Madison; Somasundaram, Veena; No, Jae Hong; Scheiblin, David A.; Garrido, Pablo; Heinz, William F.; Ryan, Aideen E.; Weiss, Jonathan M.; Cheng, Robert Y. S.; Ridnour, Lisa A.; Lockett, Stephen J.; McVicar, Daniel W.; Ambs, Stefan; Wink, David A. (Proceedings of the National Academy of Sciences, 2017-10-27)Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have ... -
Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu.
O'Flynn, Lisa; Treacy, Oliver; Ryan, Aideen E.; Morcos, Maurice; Cregg, Marese; Gerlach, Jared; Joshi, Lokesh; Nosov, Mikhail; Ritter, Thomas (Nature Publishing Group, 2013-08)Investigations into cell therapies for application in organ transplantation have grown. Here, we describe the ex vivo generation of donor bone marrow-derived dendritic cells (BMDCs) and glucocorticoid-treated BMDCs with ... -
Extracellular vesicles as modulators of wound healing
Cabral, Joana; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Elsevier, 2018-01-31)Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ... -
Immune modulation to improve tissue engineering outcomes for cartilage repair in the osteoarthritic joint
Fahy, Niamh; Farrell, Eric; Ritter, Thomas; Ryan, Aideen E.; Murphy, J. Mary (Mary Ann Liebert Inc, 2015-02-01)Osteoarthritis (OA), the most common form of arthritis, is a disabling degenerative joint disease affecting synovial joints and is associated with cartilage destruction, inflammation of the synovial membrane, and subchondral ... -
Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies
Wang, Jiemin; Donohoe, Ellen; Canning, Aoife; Moosavizadeh, Seyedmohammad; Buckley, Fiona; Brennan, Meadhbh Á.; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2023-10-23)Background Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ... -
Impact of inducible nitric oxide synthase (inos) expression on triple negative breast cancer outcome and activation of egfr and erk signaling pathways
Garrido, Pablo; Shalaby, Aliaa; Walsh, Elaine M.; Keane, Nessa; Webber, Mark; Keane, Maccon; Sullivan, Francis J; Kerin, Michael J.; Callagy, Grace; Ryan, Aideen E.; Glynn, Sharon A. (Impact Journals, LLC, 2017-07-26)Inflammation is implicated in triple negative breast cancer (TNBC) progression. TNBC carries a worse prognosis than other breast cancer subtypes, and with the clinical and molecular heterogeneity of TNBC, there is a lack ... -
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
Leonard, Niamh A. (NUI Galway, 2022-06-28)Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ... -
Mesenchymal stromal cells (mscs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?
O’Malley, Grace; Heijltjes, Madelon; Houston, Aileen M.; Rani, Sweta; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (Impact Journals, LLC, 2016-08-17)The tumour microenvironment (TME) is an important factor in determining the growth and metastasis of colorectal cancer, and can aid tumours by both establishing an immunosuppressive milieu, allowing the tumour avoid immune ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media SA, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
The role of sialylation in stromal cell-mediated immunosuppression in the colorectal tumour microenvironment
Egan, Hannah (NUI Galway, 2023-04-19)Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of many immunotherapies. The hypersialylation of cancer cells contributes significantly to this suppressive environment, aiding in tumour immune ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
O'Malley, Grace; Treacy, Oliver; Lynch, Kevin; Naicker, Serika D.; Leonard, Niamh A.; Lohan, Paul; Dunne, Philip D.; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ... -
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ... -
Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation
Lohan, Paul; Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Bingling, Chen; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Frontiers Media, 2018-11-20)High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ... -
TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung.
Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Lohan, Paul; Howard, Linda; Fahy, Gerry; Griffin, Matthew D.; Ryan, Aideen E.; Ritter, Thomas (Federation of American Society of Experimental Biology (FASEB), 2019-05-20)Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune-mediated disorders, including transplant rejection. Our group previously demonstrated the efficacy of pretransplant, systemic administration of ...